Activation of PKC isoform β1 at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain
- Author
- RIGOR, Robert R1 ; HAWKINS, Brian T1 ; MILLER, David S1
[1] Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States - Source
Journal of cerebral blood flow and metabolism. 2010, Vol 30, Num 7, pp 1373-1383, 11 p ; ref : 1 p.1/4
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- CNS drugs P-glycoprotein PKCbeta blood-brain barrier protein kinase C tumor necrosis factor alpha (TNF-α)
- Keyword (fr)
- Barrière hématoencéphalique Encéphale Facteur nécrose tumorale α Glycoprotéine Pathologie cérébrovasculaire Pathologie du système nerveux Protein kinase C Cytokine Enzyme Pathologie de l'encéphale Pathologie du système nerveux central Transferases
- Keyword (en)
- Blood brain barrier Encephalon Tumor necrosis factor α Glycoprotein Cerebrovascular disease Nervous system diseases Protein kinase C Cytokine Enzyme Cerebral disorder Central nervous system disease Transferases
- Keyword (es)
- Barrera hematoencefálica Encéfalo Factor necrosis tumoral α Glicoproteína Vaso sanguíneo encéfalo patología Sistema nervioso patología Protein kinase C Citoquina Enzima Encéfalo patología Sistema nervosio central patología Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17C Vascular diseases and vascular malformations of the nervous system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B24 Investigative techniques, diagnostic techniques (general aspects) / 002B24C Ultrasonic investigative techniques / 002B24C03 Nervous system
- Discipline
- Neurology Scanning and diagnostic techniques
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23008947
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/jcbfm.2010.21 
https://dx.doi.org/10.1038/jcbfm.2010.21
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