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1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells

Author
HAIYAN CHE1 ; TRUONG NGOC TUYEN1 2 ; HYUN PYO KIM1 ; PARK, Haeil1
[1] College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea, Republic of
[2] Ho Chi Minh University of Medicine & Pharmacy, Ho Chi Minh, Namibia
Source

Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 14, pp 4035-4037, 3 p

ISSN
0960-894X
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Author keyword
1,5-Diarylimidazoles 4-Methylsulfonylphenyl group Anti-inflammatory activity COX-2 Inhibitors Prostaglandin production
Keyword (fr)
Acide gras polyinsaturé Animal Antiinflammatoire non stéroïde Cyclooxygenase 2 Dérivé de l'acide arachidonique Dérivé de l'imidazole Dérivé du benzène In vitro Inhibiteur cyclooxygenase 2 Inhibiteur enzyme Lignée cellulaire Monocyte Prostaglandine E2 Relation structure activité Souris Sulfone Synthèse chimique Lignée RAW264 7 Enzyme Mammalia Oxidoreductases Rodentia Vertebrata
Keyword (en)
Polyunsaturated fatty acid Animal Non steroidal antiinflammatory agent Cyclooxygenase 2 Arachidonic acid derivatives Imidazole derivatives Benzene derivatives In vitro Cyclooxygenase 2 inhibitor Enzyme inhibitor Cell line Monocyte Prostaglandin E2 Structure activity relation Mouse Sulfone Chemical synthesis Enzyme Mammalia Oxidoreductases Rodentia Vertebrata
Keyword (es)
Acido graso poliinsaturado Animal Antiinflamatorio no esteroide Cyclooxygenase 2 Araquidónico ácido derivado Imidazol derivado Benceno derivado In vitro Inhibidor cyclooxygenase 2 Inhibidor enzima Línea celular Monocito Prostaglandina E2 Relación estructura actividad Ratón Sulfona Síntesis química Enzima Mammalia Oxidoreductases Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
23010392

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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