2-Phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: Synthesis and pharmacological evaluation
- Author
- DETTMANN, Sandra1 ; SZYMANOWITZ, Katrin1 ; WELLNER, Anja1 ; SCHIEDEL, Anke2 ; MÜLLER, Christa E2 ; GUST, Ronald1 3
[1] Institut für Pharmazie, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195 Berlin, Germany
[2] Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, 53115 Bonn, Germany
[3] Institut für Pharmazie, Universität Innsbruck, Innrain 52, 6020 Innsbruck, Austria - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 14, pp 4905-4916, 12 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Benzimidazoles Cytotoxicity Estrogen receptor
- Keyword (fr)
- Affinité Aminoéther Antagoniste Anticancéreux Cellule tumorale Composé aromatique Composé bicyclique Cytotoxicité Dérivé de la pipéridine Dérivé du benzimidazole Dérivé du benzène Fixation ligand Glande mammaire Homme Hétérocycle azote In vitro Isomère position Lignée cellulaire Modèle moléculaire Modélisation Phénols Relation structure activité Récepteur hormonal Récepteur oestrogène α Synthèse chimique Benzimidazolol dérivé Lignée MCF7
- Keyword (en)
- Affinity Aminoether Antagonist Antineoplastic agent Tumor cell Aromatic compound Bicyclic compound Cytotoxicity Piperidine derivatives Benzimidazole derivatives Benzene derivatives Ligand binding Mammary gland Human Nitrogen heterocycle In vitro Position isomer Cell line Molecular model Modeling Phenols Structure activity relation Hormonal receptor Estrogen receptor α Chemical synthesis
- Keyword (es)
- Afinidad Aminoeter Antagonista Anticanceroso Célula tumoral Compuesto aromático Compuesto bicíclico Citotoxicidad Piperidina derivado Benzimidazol derivado Benceno derivado Fijación ligando Glándula mamaria Hombre Heterociclo nitrógeno In vitro Isómero posición Línea celular Modelo molecular Modelización Fenoles Relación estructura actividad Receptor hormonal Receptor estrógeno α Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23054836
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2010.06.016 
https://dx.doi.org/10.1016/j.bmc.2010.06.016
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