Echinacea purpurea Significantly Induces Cytochrome P450 3A Activity but Does Not Alter Lopinavir-Ritonavir Exposure in Healthy Subjects
- Author
- PENZAK, Scott R1 ; ROBERTSON, Sarah M4 ; HUNT, Jennifer D2 ; CHAIREZ, Cheryl3 ; MALATI, Christine Y1 ; ALFARO, Raul M1 ; STEVENSON, James M5 ; KOVACS, Joseph A2
[1] Clinical Pharmacokinetics Research Laboratory, Pharmacy Department, National Institutes of Health, Bethesda, Maryland, United States
[2] Department of Critical Care Medicine, National Institutes of Health, Bethesda, Maryland, United States
[3] National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States
[4] Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Department of Health and Human Services, Silver Spring, Maryland, United States
[5] College of Pharmacy, University of Michigan, Ann Arbor, Michigan, United States - Source
Pharmacotherapy. 2010, Vol 30, Num 8, pp 797-805, 9 p ; ref : 28 ref
- CODEN
- PHPYDQ
- ISSN
- 0277-0008
- Scientific domain
- Pharmacology drugs
- Publisher
- Pharmacotherapy, Boston, MA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- CYP Echinacea purpurea HIV P-glycoprotein P-gp cytochrome P450 drug interaction herb human immunodeficiency virus lopinavir protease inhibitors ritonavir
- Keyword (fr)
- Activité biologique Antirétroviral Antiviral Cytochrome P450 Echinacea purpurea Exposition Glycoprotéine P Homme Individu sain Inhibiteur protease Interaction médicamenteuse Isozyme Lopinavir Ritonavir SIDA Virus immunodéficience humaine Cytochrome P450 3A Angiospermae Compositae Dicotyledones Enzyme Hydrolases Immunodéficit Immunopathologie Infection Inhibiteur enzyme Lentivirus Peptidases Plante florale Retroviridae Spermatophyta Virose Virus
- Keyword (en)
- Biological activity Antiretroviral agent Antiviral Cytochrome P450 Echinacea purpurea Exposure P Glycoprotein Human Healthy subject Protease inhibitor Drug interaction Isozyme Lopinavir Ritonavir AIDS Human immunodeficiency virus Angiospermae Compositae Dicotyledones Enzyme Hydrolases Immune deficiency Immunopathology Infection Enzyme inhibitor Lentivirus Peptidases Flower crop Retroviridae Spermatophyta Viral disease Virus
- Keyword (es)
- Actividad biológica Antiretroviral Antiviral Citocromo P450 Echinacea purpurea Exposición Glicoproteína P Hombre Individuo sano Inhibidor proteasa Interacción medicamentosa Isozima Lopinavir Ritonavir SIDA Human immunodeficiency virus Angiospermae Compositae Dicotyledones Enzima Hydrolases Inmunodeficiencia Inmunopatología Infección Inhibidor enzima Lentivirus Peptidases Planta floral Retroviridae Spermatophyta Virosis Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B05 Infectious diseases / 002B05C Viral diseases / 002B05C02 Human viral diseases / 002B05C02D Viral diseases of the lymphoid tissue and the blood. Aids
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B06 Immunopathology / 002B06D Immunodeficiencies. Immunoglobulinopathies / 002B06D01 Immunodeficiencies
- Discipline
- General pharmacology Immunopathology Infectious pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23055524
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1592/phco.30.8.797 
https://dx.doi.org/10.1592/phco.30.8.797
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