Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study
- Author
- EL-AZAB, Adel S1 ; AL-OMAR, Mohamed A1 ; ABDEL-AZIZ, Alaa A.-M1 ; ABDEL-AZIZ, Naglaa I2 ; EL-SAYED, Magda A.-A3 ; ALEISA, Abdulaziz M4 ; SAYED-AHMED, Mohamed M4 ; ABDEL-HAMIDE, Sami G5
[1] Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
[2] Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt
[3] Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt
[4] Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
[5] Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Kharj University, Al-Kharj, Saudi Arabia - Source
European journal of medicinal chemistry. 2010, Vol 45, Num 9, pp 4188-4198, 11 p ; ref : 38 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Kidlington
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Antitumor Drug-likeness Molecular docking Quinazoline Synthesis
- Keyword (fr)
- Anticancéreux Cellule tumorale Chlore Composé organique Col utérus Cytotoxicité Dérivé de la quinazoline Foie Glande mammaire Homme Hépatocyte In vitro Lignée HeLa Lignée cellulaire Modèle moléculaire Modélisation Relation structure activité Synthèse chimique Lignée HEPG2 Lignée MCF7 Quinazoline(6-chloro-4-toluènesulfonyl-2-p-tolyl)
- Keyword (en)
- Antineoplastic agent Tumor cell Chlorine Organic compounds Uterine cervix Cytotoxicity Quinazoline derivatives Liver Mammary gland Human Hepatocyte In vitro Hela cell line Cell line Molecular model Modeling Structure activity relation Chemical synthesis
- Keyword (es)
- Anticanceroso Célula tumoral Cloro Compuesto orgánico Cuello útero Citotoxicidad Hígado Glándula mamaria Hombre Hepatocito In vitro Célula HeLa Línea celular Modelo molecular Modelización Relación estructura actividad Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23173343
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2010.06.013 
https://dx.doi.org/10.1016/j.ejmech.2010.06.013
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