Generation of High Rapamycin Producing Strain via Rational Metabolic Pathway-Based Mutagenesis and Further Titer Improvement With Fed-Batch Bioprocess Optimization
- Author
- XIANGCHENG ZHU1 ; WEI ZHANG1 2 ; XIYANG CHEN1 ; HU WU2 ; YANWEN DUAN3 ; ZHINAN XU1
[1] Department of Chemical and Biological Engineering, Institute of Biological Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China
[2] Huadong Pharmaceutical Corp., Hangzhou, Zhejiang, China
[3] Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery, Changsha, Hunan, China - Source
Biotechnology and bioengineering. 2010, Vol 107, Num 3, pp 506-515, 10 p ; ref : 3/4 p
- CODEN
- BIBIAU
- ISSN
- 0006-3592
- Scientific domain
- Biochemistry, molecular biology, biophysics; Biotechnology
- Publisher
- Wiley, Hoboken, NJ
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- S. hygroscopicus fed-batch rapamycin rational strain improvement scale-up fermentation
- Keyword (fr)
- Amélioration génétique Amélioration procédé Dimensionnement En semi continu Fermentation Mutagenèse Optimisation Production Sirolimus Streptomyces hygroscopicus Voie métabolique Actinomycetales Actinomycetes Bactérie Streptomycetaceae
- Keyword (en)
- Genetic improvement Process improvement Dimensioning Semicontinuous Fermentation Mutagenesis Optimization Production Sirolimus Streptomyces hygroscopicus Metabolic pathway Actinomycetales Actinomycetes Bacteria Streptomycetaceae
- Keyword (es)
- Enriquecimiento genético Mejoramiento procedimiento Dimensionamiento En semicontinuo Fermentación Mutagénesis Optimización Producción Sirolimús Streptomyces hygroscopicus Vía métabolica Actinomycetales Actinomycetes Bacteria Streptomycetaceae
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology / 002A31C Methods. Procedures. Technologies / 002A31C01 Microbial engineering. Fermentation and microbial culture technology
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology / 002A31D Industrial applications and implications. Economical aspects / 002A31D01 Health. Pharmaceutical industry / 002A31D01C Production of active biomolecules / 002A31D01C8 Other active biomolecules
- Discipline
- Biotechnology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23260570
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/bit.22819 
https://dx.doi.org/10.1002/bit.22819
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