Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
- Author
- PARAYIL KUMARAN AJIKUMAR1 2 ; XIAO, Wen-Hai1 ; TYO, Keith E. J1 ; YONG WANG3 ; SIMEON, Fritz1 ; LEONARD, Effendi1 ; MUCHA, Oliver1 ; TOO HENG PHON2 ; PFEIFER, Blaine3 ; STEPHANOPOULOS, Gregory1 2
[1] Department of Chemical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, United States
[2] Chemical and Pharmaceutical Engineering Program, Singapore-MIT Alliance, 117546, Singapore
[3] Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, United States - Source
Science (Washington, D.C.). 2010, Vol 329, Num 6000, pp 70-74, 5 p
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Biosynthèse Coût Economie santé Escherichia coli Métabolisme Oxydation Paclitaxel Production Synthèse Taxus Terpénoïde Voie isoprénoïde Bactérie Coniferales Enterobacteriaceae Gymnospermae Spermatophyta
- Keyword (en)
- Antineoplastic agent Biosynthesis Costs Health economy Escherichia coli Metabolism Oxidation Paclitaxel Production Synthesis Taxus Terpenoid Isoprenoid pathway Bacteria Coniferales Enterobacteriaceae Gymnospermae Spermatophyta
- Keyword (es)
- Anticanceroso Biosíntesis Coste Economía salud Escherichia coli Metabolismo Oxidación Paclitaxel Producción Síntesis Taxus Terpenoide Vía isoprenoides Bacteria Coniferales Enterobacteriaceae Gymnospermae Spermatophyta
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23284227
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1126/science.1191652 
https://dx.doi.org/10.1126/science.1191652
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