Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry
- Author
- KASUGA, Jun-Ichi1 ; ISHIKAWA, Minoru1 ; YONEHARA, Mitsuhiro1 ; MAKISHIMA, Makoto2 ; HASHIMOTO, Yuichi1 ; MIYACHI, Hiroyuki3
[1] Institute of Molecular and Cellular Biosciences, The University ofTokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
[2] Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan
[3] Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 20, pp 7164-7173, 10 p ; ref : 36 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Aqueous solubility Molecular design Nuclear receptor PPAR agonist
- Keyword (fr)
- Acide carboxylique Affinité Agoniste partiel Carboxamide Dérivé de la benzamide Dérivé de la pyridine Dérivé du benzène Ether Hydrosolubilité Hétérocycle azote In vitro Propriété physicochimique Relation structure activité Relation structure propriété Récepteur PPAR-β Récepteur nucléaire Synthèse chimique Sélectivité Biphényle-3-carboxylique acide4p-butoxy-2,6-difluoro-3p-[(2-fluoro-4-(trifluorométhyl)benzamido)méthyl] Nicotinique acide5-[4-butoxy-3-([2-fluoro-4-(trifluorométhyl)benzamido]méthyl)phényl] Fluor Composé organique
- Keyword (en)
- Carboxylic acid Affinity Partial agonist Carboxamide Benzamide derivatives Pyridine derivatives Benzene derivatives Ether Water solubility Nitrogen heterocycle In vitro Physicochemical properties Structure activity relation Property structure relationship PPAR-β receptor Nuclear receptor Chemical synthesis Selectivity Fluorine Organic compounds
- Keyword (es)
- Acido carboxílico Afinidad Agonista parcial Carboxamida Benzamida derivado Piridina derivado Benceno derivado Eter Hidrosolubilidad Heterociclo nitrógeno In vitro Propiedad fisicoquímica Relación estructura actividad Relación estructura propiedad Receptor PPAR-β Receptor nuclear Síntesis química Selectividad Fluor Compuesto orgánico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23324155
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2010.08.041 
https://dx.doi.org/10.1016/j.bmc.2010.08.041
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