Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells
- Author
- WEI LING CHUA, Angeline1 ; HUI SIN HAY1 5 ; RAJENDRAN, Peramaiyan1 ; SHANMUGAM, Muthu K1 ; FENG LI1 ; BIST, Pradeep3 4 ; KOAY, Evelyn S. C2 ; LIM, Lina H. K3 4 ; ALAN PREM KUMAR1 5 ; SETHI, Gautam1
[1] Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
[2] Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
[3] Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
[4] Immunology Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
[5] Cancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore - Source
Biochemical pharmacology. 2010, Vol 80, Num 10, pp 1553-1562, 10 p ; ref : 63 ref
- CODEN
- BCPCA6
- ISSN
- 0006-2952
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs; Physiology, morphology
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Butein CXCR4 HER2 Invasion Metastasis NF-κB
- Keyword (fr)
- Cellule tumorale Chimiokine CXC Facteur transcription NFκB Gène erbB2 Gène onc cellulaire Invasion Métastase Protooncogène Récepteur biologique Récepteur chimiokine CXCR4 Récepteur chimiokine Récepteur HER2 Tumeur pancréas Tumeur sein Cancer Pathologie de l'appareil digestif Pathologie de la glande mammaire Pathologie du pancréas Tumeur maligne
- Keyword (en)
- Tumor cell CXC chemokine Transcription factor NFκB erbB2 Gene C-Onc gene Invasion Metastasis Protooncogene Biological receptor CXCR4 chemokine receptor Chemokine receptor Human Epidermal growth factor Receptor 2 Pancreatic tumor Breast tumor Cancer Digestive diseases Mammary gland diseases Pancreatic disease Malignant tumor
- Keyword (es)
- Célula tumoral Quimioquina CXC Factor transcripción NFκB Gen erbB2 Gen onc celular Invasión Metástasis Protooncogen Receptor biológico Receptor quimioquina CXCR4 Receptor quimioquina Tumor pecho Cáncer Aparato digestivo patología Glándula mamaria patología Páncreas patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13C Liver. Biliary tract. Portal circulation. Exocrine pancreas / 002B13C01 Tumors
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B20 Gynecology. Andrology. Obstetrics / 002B20E Mammary gland diseases / 002B20E02 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen General pharmacology Gynecology. Andrology. Obstetrics
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23336390
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bcp.2010.07.045 
https://dx.doi.org/10.1016/j.bcp.2010.07.045
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