Crystal structures, DNA-binding and cytotoxic activities studies of Cu(II) complexes with 2-oxo-quinoline-3-carbaldehyde Schiff-bases
- Author
- LIU, Zeng-Chen1 ; WANG, Bao-Dui1 ; BO LI2 ; QIN WANG2 ; YANG, Zheng-Yin1 ; LI, Tian-Rong1 ; YONG LI1
[1] College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
[2] College of Life Science, Lanzhou University, Lanzhou 730000, China - Source
European journal of medicinal chemistry. 2010, Vol 45, Num 11, pp 5353-5361, 9 p ; ref : 36 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Kidlington
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- 2-Oxo-quinoline-3-carbaldehyde Schiff-base Crystal structure Cytotoxic activity DNA-binding
- Keyword (fr)
- Activité biologique Anticancéreux Base Schiff Cellule tumorale Col utérus Coordinat organique Cuivre II Complexe Cytotoxicité DNA Diffraction RX Fixation biologique Homme Hydrazide organique Hydrazone In vitro Lactame Leucémie promyélocytaire Lignée HL60 Lignée HeLa Lignée cellulaire Structure cristalline Structure moléculaire Synthèse chimique Benzohydrazide(N-[(1,2-dihydro-2-oxo-3-quinolyl)méthylène]) Fixation DNA Pyrrole-2-carbohydrazide(N-[(1,2-dihydro-2-oxo-3-quinolyl)méthylène]-3,4-diméthyl) Quinoléin-2-one dérivé Quinoléine-3-carbaldéhyde hydrazone dérivé Salicylohydrazide(N-[(1,2-dihydro-2-oxo-3-quinolyl)méthylène]) Métal divalent Complexe Métal transition Complexe
- Keyword (en)
- Biological activity Antineoplastic agent Schiff base Tumor cell Uterine cervix Organic ligand Copper II Complexes Cytotoxicity DNA X ray diffraction Biological fixation Human Organic hydrazide Hydrazone In vitro Lactam Promyelocytic leukemia HL60 cell line Hela cell line Cell line Crystalline structure Molecular structure Chemical synthesis Divalent metal Complexes Transition metal Complexes
- Keyword (es)
- Actividad biológica Anticanceroso Base Schiff Célula tumoral Cuello útero Ligando orgánico Cobre II Complejo Citotoxicidad DNA Difracción RX Fijación biológica Hombre Hidrácida orgánica Hidrazona In vitro Lactamo Leucemia promielocítica Línea HL60 Célula HeLa Línea celular Estructura cristalina Estructura molecular Síntesis química Metal divalente Complejo Metal transición Complejo
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23367561
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2010.08.060 
https://dx.doi.org/10.1016/j.ejmech.2010.08.060
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