Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols
- Author
- TEWES, Bastian1 ; FREHLAND, Bastian1 ; SCHEPMANN, Dirk1 ; SCHMIDTKE, Kai-Uwe2 ; WINCKLER, Thomas2 ; WÜNSCH, Bernhard1
[1] Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Hittorfstrasse 58-62, 48149 Münster, Germany
[2] Institut für Pharmazie der Friedrich-Schiller-Universität Jena, Semmelweisstrasse 10, 07743 Jena, Germany - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 22, pp 8005-8015, 11 p ; ref : 39 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 3-Benzazepines NR2B selective NMDA receptor antagonists Neuropathic pain Neuroprotection Structure-activity relationships
- Keyword (fr)
- Affinité Aminoalcool Analgésique Animal Antagoniste Composé bicyclique Encombrement stérique Hétérocycle azote In vitro In vivo Neuroprotecteur Phénols Relation structure activité Rigidité moléculaire Récepteur NMDA Récepteur glutamate Souris Synthèse chimique Sélectivité Voie intrapéritonéale 3-Benzoazépine-1,7-diol(3-[4-phénylbutyl]-2,3,4,5-tétrahydro) Sous-unité NMDA R2B Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Aminoalcohol Analgesic Animal Antagonist Bicyclic compound Steric hindrance Nitrogen heterocycle In vitro In vivo Neuroprotective agent Phenols Structure activity relation Molecular rigidity NMDA receptor Glutamate receptor Mouse Chemical synthesis Selectivity Intraperitoneal administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Aminoalcohol Analgésico Animal Antagonista Compuesto bicíclico Embarazo estérico Heterociclo nitrógeno In vitro In vivo Neuroprotector Fenoles Relación estructura actividad Rigidez molecular Receptor NMDA Receptor glutámato Ratón Síntesis química Selectividad Vía intraperitoneal Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B05 Analgesics
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09E Glutamatergic system (aspartate and other excitatory aminoacids)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B10 Neuroprotective agent
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23420800
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2010.09.026 
https://dx.doi.org/10.1016/j.bmc.2010.09.026
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