New class of potent antitumor acylhydrazone derivatives containing furan
- Author
- ZINING CUI1 ; YING LI1 ; YUN LING1 ; JUAN HUANG1 ; JINGRONG CUI2 ; RUIQING WANG2 ; XINLING YANG1
[1] Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China
[2] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100083, China - Source
European journal of medicinal chemistry. 2010, Vol 45, Num 12, pp 5576-5584, 9 p ; ref : 48 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Kidlington
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Acylhydrazone Antitumor activity Configurational isomer Synthesis Toxicity
- Keyword (fr)
- Aldéhyde Anticancéreux Carcinogène Cellule tumorale Cytotoxicité Diffraction RX Dérivé du benzaldéhyde Dérivé du benzène Dérivé du furane Dérivé du furfural Epiderme Estomac Foie Homme Hydrazide organique Hydrazone In vitro Leucémie promyélocytaire Lignée HL60 Lignée KB Lignée cellulaire Mutagène Prédiction Relation structure activité Structure cristalline Structure moléculaire Synthèse chimique Toxicité 2-Furoïque acide(5-aryl) benzylidènehydrazide Acide aroïque 5-arylfurfurylidènehydrazide Carcinogénicité Lignée BGC823 Lignée bel 7402 Mutagénicité
- Keyword (en)
- Aldehyde Antineoplastic agent Carcinogen Tumor cell Cytotoxicity X ray diffraction Benzaldehyde derivatives Benzene derivatives Furan derivatives Furfural derivatives Epidermis Stomach Liver Human Organic hydrazide Hydrazone In vitro Promyelocytic leukemia HL60 cell line KB cell line Cell line Mutagen Prediction Structure activity relation Crystalline structure Molecular structure Chemical synthesis Toxicity
- Keyword (es)
- Aldehído Anticanceroso Carcinógeno Célula tumoral Citotoxicidad Difracción RX Benzaldehído derivado Benceno derivado Furano derivado Furfural derivado Epidermis Estómago Hígado Hombre Hidrácida orgánica Hidrazona In vitro Leucemia promielocítica Línea HL60 Célula KB Línea celular Mutágeno Predicción Relación estructura actividad Estructura cristalina Estructura molecular Síntesis química Toxicidad
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23474144
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2010.09.007 
https://dx.doi.org/10.1016/j.ejmech.2010.09.007
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