Salicylate restores transport function and anion exchanger activity of missense pendrin mutations

Author

ISHIHARA, Kenji^{1 2} ; OKUYAMA, Shuhei¹ ; TSUMOTO, Kohei⁷ ; NAKAMURA, Hiroyuki⁸ ; HIRASAWA, Noriyasu⁹ ; WADA, Hiroshi¹ ; KUMANO, Shun¹ ; IIDA, Koji¹ ; HAMANA, Hiroshi¹ ; MURAKOSHI, Michio¹ ; KOBAYASHI, Toshimitsu³ ; USAMI, Shinichi⁴ ; IKEDA, Katsuhisa⁵ ; HAGA, Yoichi⁶
[1] Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579, Japan
[2] Laboratory of Medical Science, Course for School Nurse Teacher, Faculty of Education, Ibaraki University, 310-8512, Japan
[3] Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Tohoku University, 980-8575, Japan
[4] Department of Otorhinolaryngology. Shinshu University School of Medicine, 390-8621, Japan
[5] Department of Otorhinolaryngology, Juntendo University School of Medicine, 113-8421, Japan
[6] Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 980-8579, Japan
[7] Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 277-8562, Japan
[8] Department of Chemistry, Faculty of Science, Gakusyuin University, 171-8588, Japan
[9] Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, 980-8578, Japan

Source

Hearing research. 2010, Vol 270, Num 1-2, pp 110-118, 9 p ; ref : 3/4 p

CODEN

HERED3

ISSN

0378-5955

Scientific domain

Otorhinolaryngology, stomatology, dentistry; Physiology, morphology

Publisher

Elsevier, Amsterdam

Publication country

Netherlands

Document type

Article

Language

English

Keyword (fr)

Chlorure Echangeur anion Endolymphe Gène Homme Homéostasie Hydrogénocarbonate Ion Mutation faux sens Oreille interne Protéine transmembranaire Salicylés Surdité Syndrome de Pendred Transport biologique Appareil auditif Endocrinopathie Maladie héréditaire Pathologie ORL Pathologie de la thyroïde Trouble de l'audition

Keyword (en)

Chlorides Anion exchanger Endolymph Gene Human Homeostasis Hydrogencarbonates Ions Missense mutation Inner ear Transmembrane protein Salicylates Hearing loss Pendred syndrome Biological transport Organ of hearing Endocrinopathy Genetic disease ENT disease Thyroid diseases Auditory disorder

Keyword (es)

Cloruro Cambiador aniónico Endolinfa Gen Hombre Homeostasis Hidrógenocarbonato Ión Mutación falso sentido Oido interno Proteína transmembranar Salicilatos Sordera Pendred síndrome Transporte biológico Aparato auditivo Endocrinopatía Enfermedad hereditaria ORL patología Tiroides patología Trastorno auditivo

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A25 Vertebrates: nervous system and sense organs / 002A25H Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B10 Otorhinolaryngology. Stomatology / 002B10D Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology / 002B10D02 Non tumoral diseases

Discipline

Otorhinolaryngology. Stomatology Vertebrates : nervous system and sense organs

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

23661012

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS