Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors
- Author
- QIONG YANG1 2 ; KÖTTGEN, Anna3 ; LAUNER, Lenore8 ; NALLS, Michael2 ; HERNANDEZ, Dena2 ; ARKING, Dan E2 ; BOERWINKLE, Eric9 ; GROVE, Megan L10 ; MAN LI3 ; KAO, W. H. Linda3 ; CHONCHOL, Michel11 ; HARITUNIANS, Talin12 ; DEHGHAN, Abbas4 ; GUO LI6 ; LUMLEY, Thomas13 ; PSATY, Bruce M14 ; SHLIPAK, Michael15 ; HWANG, Shih-Jen16 ; LARSON, Martin G17 ; O'DONNELL, Christopher J18 ; UPADHYAY, Ashish19 ; VAN DUIJN, Cornelia M4 ; HOFMAN, Albert2 ; SMITH, Albert V5 ; RIVADENEIRA, Fernando20 ; STRICKER, Bruno2 ; UITTERLINDEN, Andre G; PARE, Guillaume21 ; PARKER, Alex N22 ; RIDKER, Paul M23 ; SISCOVICK, David S24 ; GUDNASON, Vilmundur25 ; WITTEMAN, Jacqueline C2 ; FOX, Caroline S; GLAZER, Nicole L6 ; CORESH, Josef3 ; CHEN, Ming-Huei2 ; CHASMAN, Daniel I2 ; ASPELUND, Thor5 7 ; EIRIKSDOTTIR, Gudny5 ; HARRIS, Tamara B8
[1] Department of Biostatistics , Boston University School of Public Health, Boston, Mass, United States
[2] NHLBI's Framingham Heart Study, Framingham, Mass, United States
[3] Department of Epidemiology Johns Hopkins University, Baltimore, Md, United States
[4] Department of Epidemiology Erasmus Medical Center, Rotterdam, Netherlands
[5] Icelandic Heart Association, Kopavogur, Iceland
[6] Cardiovascular Health Research Unit and Department of Medicine University of Washington, Seattle, Wa, United States
[7] University of Iceland, Reykjavik, Iceland
[8] Laboratory of Epidemiology, Demography, and Biometry Intramural Research Program, National Institute on Aging, Bethesda, Md, United States
[9] Human Genetics Center and Division of Epidemiology University of Texas Health Science Center at Houston, Houston, Tex; McKusick-Nathans Institute of Genetic Medicine Johns Hopkins Medical Institute, Baltimore, Md, United States
[10] Human Genetics Center University of Texas Health Science Center at Houston, Houston, Tex, United States
[11] Department of Medicine Johns Hopkins University, Baltimore, Md, United States
[12] Division of Renal Diseases and Hypertension University of Colorado Denver Health Sciences Center, Aurora, Colo, United States
[13] Medical Genetics Institute Cedars-Sinai Medical Center, Los Angeles, Calif, United States
[14] Department of Biostatistics University of Washington, Seattle, Wa, United States
[15] Cardiovascular Health Research Unit and Department of Medicine Epidemiology and Health Services, University of Washington, Seattle, and Center for Health Studies, Group Health, Seattle, Wa, United States
[16] General Internal Medicine Division San Francisco VA Medical Center, University of California, San Francisco, Calif, United States
[17] Department of Neurology , Boston University, Boston, Mass, United States
[18] Department of Mathematics and Statistics , Boston University, Boston, Mass, United States
[19] The Center for Population Studies , National Heart, Lung, and Blood Institute, Bethesda, Md, United States
[20] Cardiology Division Massachusetts General Hospital, Boston, Mass, United States
[21] Renal Section , Boston Medical Center and Boston University School of Medicine, Boston, Mass, United States
[22] Department of Internal Medicine , Erasmus Medical Center, Rotterdam, Netherlands
[23] Cardiovascular Health Research Unit and Department of Medicine and Epidemiology University of Washington, Seattle, Wa, United States
[24] Division of Endocrinology, Hypertension, & Metabolism Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, United States
[25] Department of Biostatistics Johns Hopkins University, Baltimore, Md, United States - Source
Circulation. Cardiovascular genetics (Print). 2010, Vol 3, Num 6, pp 523-530, 8 p ; ref : 25 ref
- ISSN
- 1942-325X
- Scientific domain
- Cardiology, blood circulation, phlebology
- Publisher
- Lippincott Williams & Wilkins, Hagerstown, MD
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- Mendelian randomization analysis cardiovascular diseases genome-wide association study gout risk factors uric acid
- Keyword (fr)
- Acide urique Adulte Athérosclérose Cardiopathie coronaire Coeur Déterminisme génétique Epidémiologie Etude cohorte Facteur risque Facteur sérique Femelle Femme Filtration glomérulaire Glucose Goutte (pathologie) Génome Génétique Homme Locus Microcristal Multiple Métaanalyse Méthode analyse Néphropathie chronique Néphropathie glomérulaire Pathologie de l'appareil circulatoire Phénotype Polymorphisme mononucléotide Population Pression artérielle Pression sanguine Purine Ratio Santé Sérum Association génétique Linkage Arthropathie microcristalline Hyperuricémie Insuffisance rénale Maladie métabolique Pathologie de l'appareil urinaire Pathologie des vaisseaux sanguins Pathologie du rein Pathologie du système ostéoarticulaire
- Keyword (en)
- Uric acid Adult Atherosclerosis Coronary heart disease Heart Genetic determinism Epidemiology Cohort study Risk factor Serum factor Female Woman Glomerular filtration Glucose Gout Genome Genetics Human Locus Microcrystal Multiple Metaanalysis Analysis method Chronic kidney disease Glomerulonephritis Cardiovascular disease Phenotype Single nucleotide polymorphism Population Arterial pressure Blood pressure Purine Ratio Health Serum Microcristalline arthropathy Hyperuricemia Renal failure Metabolic diseases Urinary system disease Vascular disease Kidney disease Diseases of the osteoarticular system
- Keyword (es)
- Urico ácido Adulto Ateroesclerosis Cardiopatía coronaria Corazón Determinismo genético Epidemiología Estudio cohorte Factor riesgo Factor sérico Hembra Mujer Filtración glomerular Glucosa Gota (patología) Genoma Genética Hombre Locus Microcristal Múltiple Meta-análisis Método análisis Nefropatía crónica Nefropatía glomerular Aparato circulatorio patología Fenotipo Polimorfismo mononucleótido Población Presión arterial Presión sanguínea Purina Ratio Salud Suero Artropatía por microcristales Hiperuricemia Insuficiencia renal Metabolismo patología Aparato urinario patología Vaso sanguíneo patología Riñón patología Sistema osteoarticular patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B12 Cardiology. Vascular system / 002B12B Blood and lymphatic vessels / 002B12B01 Atherosclerosis (general aspects, experimental research)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15D Inflammatory joint diseases
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15I Miscellaneous. Osteoarticular involvement in other diseases
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B22 Metabolic diseases / 002B22E Other metabolic disorders / 002B22E01 Purines and pyrimidines (gout, hyperuricemia...)
- Discipline
- Cardiology. Circulatory system Metabolic diseases Osteoarticular pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23711597
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1161/CIRCGENETICS.109.934455 
https://dx.doi.org/10.1161/CIRCGENETICS.109.934455
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arXiv access
