Mechanisms underlying resistance to cetuximab in the HNSCC cell line: Role of AKT inhibition in bypassing this resistance
- Author
- REBUCCI, Magali1 2 3 ; PEIXOTO, Paul1 3 ; LARTIGAU, Eric2 4 ; LANSIAUX, Amélie1 2 3 4 ; DEWITTE, Amélie1 3 ; WATTEZ, Nicole1 2 3 ; DE NUNCQUES, Marie-Adeline1 ; REZVOY, Nicolas1 2 ; VAUTRAVERS-DEWAS, Claire1 ; BUISINE, Marie-Pierre1 4 5 ; GUERIN, Eric6 7 ; PEYRAT, Jean-Philippe2
[1] Jean-Pierre Aubert Research Center (JPARC) INSERM U837, 59045 Lille, France
[2] Centre Oscar Lambret, 59020 Lille, France
[3] Institut pour la Recherche sur le Cancer de Lille (IRCL), 59045 Lille, France
[4] Université Lille Nord de France, Faculté de Médecine, 59045 Lille, France
[5] CHRU de Lille, 59037 Lille, France
[6] Université de Strasbourg (UdS), EA4438 Physiopathologie et Médecine Translationnelle, Bâtiment INSERM U682, 67200 Strasbourg, France
[7] Laboratoire de Biochimie et Biologie Moléculaire, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, 67098 Strasbourg, France - Source
International journal of oncology. 2011, Vol 38, Num 1, pp 189-200, 12 p ; ref : 56 ref
- ISSN
- 1019-6439
- Scientific domain
- Medical oncology
- Publisher
- Editorial Academy of the International Journal of Oncology, Athens
- Publication country
- Greece
- Document type
- Article
- Language
- English
- Author keyword
- AKT pathway EGFR internalization gefitinib cetuximab epidermal growth factor receptor phosphatidylinositol 3-kinase inhibitor
- Keyword (fr)
- 1-Phosphatidylinositol 3-kinase Akt protein kinase Anticancéreux Cancérologie Carcinome épidermoïde de la tête et du cou Cétuximab Géfitinib Internalisation Lignée cellulaire établie Mécanisme Récepteur facteur croissance épiderme Récepteur facteur croissance Résistance Anti-EGFR Anticorps monoclonal Cancer Dérivé de la quinazoline Enzyme Inhibiteur de la tyrosine kinase Inhibiteur enzyme Pathologie ORL Protein-tyrosine kinase Transferases Tumeur maligne
- Keyword (en)
- 1-Phosphatidylinositol 3-kinase Akt protein kinase Antineoplastic agent Cancerology Head and neck squamous cell carcinoma Cetuximab Gefitinib Internalization Established cell line Mechanism Epidermal growth factor receptor Growth factor receptor Resistance Monoclonal antibody Cancer Quinazoline derivatives Enzyme Tyrosine kinase inhibitor Enzyme inhibitor ENT disease Protein-tyrosine kinase Transferases Malignant tumor
- Keyword (es)
- 1-Phosphatidylinositol 3-kinase Akt protein kinase Anticanceroso Cancerología Carcinoma epidermoideo cabeza cuello Cetuximab Gefitinib Internalización Línea celular establecida Mecanismo Receptor del factor de crecimiento epidérmico Receptor factor crecimiento Resistencia Anticuerpo monoclonal Cáncer Enzima Inhibidor tyrosine kinase Inhibidor enzima ORL patología Protein-tyrosine kinase Transferases Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B10 Otorhinolaryngology. Stomatology / 002B10A Otorhinolaryngology (head neck, general aspects and miscellaneous) / 002B10A01 Tumors
- Discipline
- Otorhinolaryngology. Stomatology Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 23744241
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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