Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK
- Author
- DAS, Joydeep1 ; GHOSH, Jyotirmoy1 ; MANNA, Prasenjit1 ; SIT, Parames C1
[1] Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, West Bengal, India - Source
Biochemical pharmacology. 2011, Vol 81, Num 7, pp 891-909, 19 p ; ref : 70 ref
- CODEN
- BCPCA6
- ISSN
- 0006-2952
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs; Physiology, morphology
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Antioxidant Apoptosis Cardiac oxidative stress Cell survival Doxorubicin NF-κB and MAPK PI3-K/Akt Reactive oxygen species Taurine p53
- Keyword (fr)
- 1-Phosphatidylinositol 3-kinase Akt protein kinase Animal Antibiotique Anticancéreux Antioxydant Apoptose Coeur Doxorubicine Espèces réactives de l'oxygène Facteur transcription NFκB Gène TP53 Gène suppresseur tumeur Mitogen-activated protein kinase Mort cellulaire Protéine p53 Rat Stress oxydatif Taurine Gène p53 Survie cellulaire c-Jun N-terminal kinase Aminoacide Anthracyclines Appareil circulatoire DNA topoisomerase (ATP-hydrolysing) Enzyme Inhibiteur de la topoisomérase II Inhibiteur enzyme Isomerases Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- 1-Phosphatidylinositol 3-kinase Akt protein kinase Animal Antibiotic Antineoplastic agent Antioxidant Apoptosis Heart Doxorubicin Reactive oxygen species Transcription factor NFκB TP53 Gene Tumor suppressor gene Mitogen-activated protein kinase Cell death p53 Protein Rat Oxidative stress Taurine Cell survival Aminoacid Anthracyclins Circulatory system DNA topoisomerase (ATP-hydrolysing) Enzyme Topoisomerase II inhibitor Enzyme inhibitor Isomerases Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- 1-Phosphatidylinositol 3-kinase Akt protein kinase Animal Antibiótico Anticanceroso Antioxidante Apoptosis Corazón Doxorubicina Especies reactivas del oxígeno Factor transcripción NFκB Gen TP53 Gen supresor tumor Mitogen-activated protein kinase Muerte celular Proteína p53 Rata Estrés oxidativo Taurina Supervivencia celular Aminoácido Antraciclinas Aparato circulatorio DNA topoisomerase (ATP-hydrolysing) Enzima Inhibidor topoisomerase II Inhibidor enzima Isomerases Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A07 Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24013845
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bcp.2011.01.008 
https://dx.doi.org/10.1016/j.bcp.2011.01.008
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