Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages

Author

AN, Hyo-Jin¹ ; KIM, In-Tae¹ ; PARK, Hee-Juhn² ; KIM, Hyung-Min³ ; CHOI, Jung-Hye^{4 5} ; LEE, Kyung-Tae^{1 5}
[1] Department of Pharmaceutical Biochemistry, College of Pharmary, Kyung Hee University, Seoul 130-701, Korea, Republic of
[2] Department of Pharmaceutical Engineering, Sangji University, Wonju, Korea, Republic of
[3] Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, Seoul, Korea, Republic of
[4] Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Korea, Republic of
[5] Department of Life and Nanopharmaceutical Sciences, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea, Republic of

Source

International immunopharmacology (Print). 2011, Vol 11, Num 4, pp 504-510, 7 p ; ref : 33 ref

ISSN

1567-5769

Scientific domain

Immunology, immunopathology, allergology; Pharmacology drugs

Publisher

Elsevier, Kidlington

Publication country

United Kingdom

Document type

Article

Language

English

Author keyword

Nitric oxide Nuclear factor-κB (NF-κB) Raw 264.7 cells Rosa rugosa Tormentic acid

Keyword (fr)

Acide Cyclooxygenase 2 Facteur nécrose tumorale α Facteur transcription NFκB In vitro Inactivation Inhibiteur Lipopolyoside Macrophage Monoxyde d'azote Nitric-oxide synthase Rosa Saponine Terpénoïde Triterpène Angiospermae Cytokine Dicotyledones Enzyme Oxidoreductases Rosaceae Spermatophyta

Keyword (en)

Acids Cyclooxygenase 2 Tumor necrosis factor α Transcription factor NFκB In vitro Inactivation Inhibitor Lipopolysaccharide Macrophage Nitric oxide Nitric-oxide synthase Rosa Saponin Terpenoid Triterpene Angiospermae Cytokine Dicotyledones Enzyme Oxidoreductases Rosaceae Spermatophyta

Keyword (es)

Acido Cyclooxygenase 2 Factor necrosis tumoral α Factor transcripción NFκB In vitro Inactivación Inhibidor Lipopoliósido Macrófago Nitrógeno monóxido Nitric-oxide synthase Rosa Saponina Terpenoide Triterpeno Angiospermae Citoquina Dicotyledones Enzima Oxidoreductases Rosaceae Spermatophyta

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments

Discipline

General pharmacology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

24016430

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS