Synthesis of 2'-O-[2-(N-Methylcarbamoyl)ethyl]ribonucleosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide Derivatives Incorporating These Modified Ribonucleosides
- Author
- YAMADA, Takeshi1 ; OKANIWA, Natsuki1 ; SANEYOSHI, Hisao1 ; OHKUBO, Akihiro1 ; SEIO, Kohji1 ; NAGATA, Tetsuya2 ; AOKI, Yoshitsugu2 ; TAKEDA, Shin'ichi2 ; SEKINE, Mitsuo1
[1] Department of Life Science, Tokyo Institute of Technology, J2-12, 4259 Nagatsuta, Midoriku, Yokohama 226-8501, Japan
[2] Department of Molecular Therapy, Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan - Source
Journal of organic chemistry. 2011, Vol 76, Num 9, pp 3042-3053, 12 p ; ref : 42 ref
- CODEN
- JOCEAH
- ISSN
- 0022-3263
- Scientific domain
- Biochemistry, molecular biology, biophysics; Organic chemistry
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide nucléique Addition Michaël Affinité DNA Epissage Groupe hydroxyle Hybridation Hétérocycle oxygène Milieu basique Médicament Nuclease Nucléoside Nucléotide Oligomère Oligonucléotide Oligoribonucléotide Phosphoramidite organique Phosphore Composé organique Propriété biologique Protection RNA complémentaire RNA messager Ribonucléoside Souris Synthèse chimique Thiophosphate organique Uridine Enzyme Esterases Hydrolases Mammalia Rodentia Vertebrata
- Keyword (en)
- Nucleic acid Michael addition Affinity DNA Splicing Hydroxyl group Hybridization Oxygen heterocycle Basic medium Drug Nuclease Nucleoside Nucleotide Oligomer Oligonucleotide Oligoribonucleotide Organic phosphoramidite Phosphorus Organic compounds Biological properties Protection Complementary RNA Messenger RNA Ribonucleoside Mouse Chemical synthesis Organic thiophosphate Uridine Enzyme Esterases Hydrolases Mammalia Rodentia Vertebrata
- Keyword (es)
- Acido nucleico Adición Michael Afinidad DNA Empalme Grupo hidróxilo Hibridación Heterociclo oxígeno Medio básico Medicamento Nuclease Nucleósido Nucleótido Oligómero Oligonucleótido Oligorribonucleótido Fosforamidito orgánico Fósforo Compuesto orgánico Propiedad biológica Protección ARN complementario RNA mensajero Ribonucleósido Ratón Síntesis química Tiofosfato orgánico Uridina Enzima Esterases Hydrolases Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06A Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C07 Carbohydrates. Nucleosides and nucleotides / 001C03C07B Nucleosides, nucleotides and oligonucleotides
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02C Nucleic acids / 002A02C03 Dna, deoxyribonucleoproteins
- Discipline
- Analytical, structural and metabolic biochemistry Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24118242
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jo101963z 
https://dx.doi.org/10.1021/jo101963z
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