Inhalation by design: Dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD
- Author
- JONES, Lyn H1 ; BALDOCK, Helen1 ; HILTON, Laura1 ; JAMES, Kim1 ; JONES, Rhys M4 ; KENYON, Amy S1 ; MARSHALL, Stuart1 2 ; NEWMAN, Sandra D1 ; OSBORNE, Rachel1 ; PATEL, Sheena3 ; SELBY, Matthew D1 ; STUART, Emilio F3 ; BUNNAGE, Mark E1 ; TREVETHICK, Michael A3 ; WRIGHT, Karen N3 ; PRICE, David A1 ; BURROWS, Jane2 ; CLARKE, Nick3 ; COGHLAN, Michele3 ; ENTWISTLE, David2 ; FAIRMAN, David4 ; FEEDER, Neil2 ; FULTON, Craig2
[1] Sandwich Chemistry, World Wide Medicinal Chemistry, Pfizer, Ramsgate Road, Sandwich CT13 9NJ, United Kingdom
[2] Pharmaceutical Sciences, Pfizer, Ramsgate Road, Sandwich CT13 9NJ, United Kingdom
[3] Allergy and Respiratory Biology, Pfizer, Ramsgate Road, Sandwich CT13 9NJ, United Kingdom
[4] Pharmacokinetics, Dynamics and Metabolism, Pfizer, Ramsgate Road, Sandwich CT13 9NJ, United Kingdom - Source
Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 9, pp 2759-2763, 5 p ; ref : 39 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- COPD Crystallinity Dual pharmacology Inhalation MABA
- Keyword (fr)
- Affinité Agoniste Aminoalcool Aminophénols Antagoniste Bronchodilatateur Bronchopneumopathie chronique obstructive Composé aromatique Composé bicyclique Durée action Dérivé du benzène Ether Ex vivo Hétérocycle azote In vitro Inhalation Lactame Lipophilie Propriété physicochimique Relation propriété physicochimique activité Relation structure activité Relation structure propriété Récepteur cholinergique Récepteur muscarinique M3 Récepteur β2-adrénergique Traitement Phénol dérivé Quinoléin-2-one dérivé
- Keyword (en)
- Affinity Agonist Aminoalcohol Aminophenols Antagonist Bronchodilator Chronic obstructive pulmonary disease Aromatic compound Bicyclic compound Duration of action Benzene derivatives Ether Ex vivo Nitrogen heterocycle In vitro Inhalation Lactam Lipophilicity Physicochemical properties Physicochemical properties activity relationship Structure activity relation Property structure relationship Cholinergic receptor M3 Muscarinic receptor β2-Adrenergic receptor Treatment
- Keyword (es)
- Afinidad Agonista Aminoalcohol Aminofenoles Antagonista Broncodilatador Enfermedad pulmonar obstructiva crónica Compuesto aromático Compuesto bicíclico Duración acción Benceno derivado Eter Ex vivo Heterociclo nitrógeno In vitro Inhalación Lactamo Lipofilia Propiedad fisicoquímica Relación propiedad fisicoquímica actividad Relación estructura actividad Relación estructura propiedad Receptor colinérgico Receptor muscarínico M3 Receptor β2-adrenérgico Tratamiento
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09B Cholinergic system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02D Respiratory system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24154383
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2010.10.132 
https://dx.doi.org/10.1016/j.bmcl.2010.10.132
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