Activity Levels ofTamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes.on Their Concentration Levels in Plasma

Author

MÜRDTER, T. E^{1 2} ; SCHROTH, W^{1 2} ; BRAUCH, H^{1 2} ; BACCHUS-GERYBADZE, L^{1 2 3} ; WINTER, S^{1 2} ; HEINKELE, G^{1 2} ; SIMON, W⁴ ; FASCHING, P. A^{5 6} ; FEHM, T⁷ ; EICHELBAUM, M^{1 2} ; SCHWAB, M^{1 2 8}
[1] Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
[2] University of Tübingen, Tübingen, Germany
[3] Department of Hematology and Oncology, Robert Bosch Hospital, Stuttgart, Germany
[4] Department of Gynecology, Robert Bosch Hospital, Stuttgart, Germany
[5] Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Erlangen, Germany
[6] Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States
[7] University Breast Center Tübingen, Department of Gynecology and Obstetrics, University of Tübingen, Tübingen, Germany
[8] Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany

Source

Clinical pharmacology and therapeutics. 2011, Vol 89, Num 5, pp 708-717, 10 p ; ref : 46 ref

CODEN

CLPTAT

ISSN

0009-9236

Scientific domain

Pharmacology drugs

Publisher

Nature Publishing Group, Basingstoke

Publication country

United Kingdom

Document type

Article

Language

English

Keyword (fr)

Activité biologique Concentration Essai clinique phase I Essai clinique phase II Génotype Homme Liquide biologique Métabolite Plasma sanguin Polymorphisme Récepteur hormonal Récepteur oestrogène Variabilité génétique

Keyword (en)

Biological activity Concentration Phase I trial Phase II trial Genotype Human Biological fluid Metabolite Blood plasma Polymorphism Hormonal receptor Estrogen receptor Genetic variability

Keyword (es)

Actividad biológica Concentración Ensayo clínico fase I Ensayo clínico fase II Genotipo Hombre Líquido biológico Metabolito Plasma sanguíneo Polimorfismo Receptor hormonal Receptor estrógeno Variabilidad genética

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments

Discipline

General pharmacology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

24182106

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS