The Use of Solid Dispersion Systems in Hydrophilic Carriers to Increase Benznidazole Solubility
- Author
- LIMA, Adley A. N1 4 ; SOARES-SOBRINHO, Jose L1 3 ; SILVA, Jeckson L1 ; CORREA-JUNIOR, Roberto A. C1 ; LYRA, Magaly A. M1 ; SANTOS, Fabiana L. A1 ; OLIVEIRA, Boaz G2 ; HERNANDES, Marcelo Z2 ; ROLIM, Larissa A1 ; ROLIM-NETO, Pedro J1
[1] Laboratorio de Tecnologia dos Medicamentos, Departamento de Ciencias Farmaceuticas, Universidade Federal de Pernambuco, Rua Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521 Recife ― PE, Brazil
[2] Laboratório de Química Teórica Medicinal, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Rua Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-52 Recife ― PE, Brazil
[3] Núcleo de Tecnologia Farmaceutica, Universidade Federal do Piauí, Campus Universitário Ministro Petrônio Portella, Ininga, 64.049-550 Teresina ― PI, Brazil
[4] Laboratório de Controle de Qualidade de medicamentos, Faculdade de Ciências Farmaceuticas, Universidade Federal do Amazonas, Rua Alexandre Amorim, no. 330, Aparecida, 69010-330 Manaus ― AM, Brazil - Source
Journal of pharmaceutical sciences. 2011, Vol 100, Num 6, pp 2443-2451, 9 p ; ref : 18 ref
- CODEN
- JPMSAE
- ISSN
- 0022-3549
- Scientific domain
- Pharmacology drugs
- Publisher
- American Pharmaceutical Association, Washington, DC
/
Wiley, Hoboken, NJ
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- benznidazole dissolution molecular modeling polyethylene glycol polymeric drug carrier polyvinylpyrrolidone solid dispersion solubility
- Keyword (fr)
- Antiparasitaire Antiprotozoaire Benznidazole Dispersion solide Dissolution Ether cyclique polymère Ethylène oxyde polymère Hydrophilie Modèle moléculaire Polymère vecteur Povidone Pyrrolidone(vinyl) polymère Solubilité Succédané plasma Technologie pharmaceutique Vecteur médicament Composé nitro Dérivé de l'imidazole Propriété physicochimique
- Keyword (en)
- Parasiticide Antiprotozoal agent Benznidazole Solid dispersion Dissolution Cyclic ether polymer Ethylene oxide polymer Hydrophily Molecular model Control release polymer Povidone Pyrrolidone(vinyl) polymer Solubility Plasma substitute Pharmaceutical technology Drug carrier Nitro compound Imidazole derivatives Physicochemical properties
- Keyword (es)
- Antiparasitario Antiprotozoario Benznidazol Dispersión sólida Disolución Eter cíclico polímero Etileno óxido polímero Hidrofilia Modelo molecular Polímero vector Povidona Pirrolidona(vinil) polímero Solubilidad Substituto plasma Tecnología farmacéutica Vector medicamento Compuesto nitro Imidazol derivado Propiedad fisicoquímica
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A03 Pharmaceutical technology. Pharmaceutical industry
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24186714
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/jps.22436 
https://dx.doi.org/10.1002/jps.22436
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