CoMFA-based prediction of agonist affinities at recombinant D1 vs D2 dopamine receptors
- Author
- WILCOX, R. E1 2 ; TSENG, T1 ; BRUSNIAK, M.-Y. K3 ; GINSBURG, B1 ; PEARLMAN, R. S3 ; TEETER, M4 ; DURAND, C5 ; STARR, S6 ; NEVE, K. A6
[1] Molecular Pharmacology Laboratory, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712-1074, United States
[2] Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, United States
[3] Laboratory for Molecular Graphics and Theoretical Modeling, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States
[4] Laboratory of Protein Modeling, Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02167, United States
[5] Psychiatry Service, VA Medical Center, Department of Veterans Affairs, Bedford, Massachusetts 01730, United States
[6] Medical Research Service, Department of Veterans Affairs Medical Center, Portland, Oregon 97201, United States - Source
Journal of medicinal chemistry (Print). 1998, Vol 41, Num 22, pp 4385-4399
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Agoniste Animal Effet stérique Effet électrostatique Homologie Lignée cellulaire établie Modèle 3 dimensions Modèle moléculaire Modélisation Médicament Prédiction Rat Relation structure activité Récepteur dopaminergique D1 Récepteur dopaminergique D2 Similitude Lignée C6 Méthode CoMFA Pharmacophore Mammalia Rodentia Vertebrata
- Keyword (en)
- Agonist Animal Steric effect Electrostatic effect Homology Established cell line Three dimensional model Molecular model Modeling Drug Prediction Rat Structure activity relation D1 Dopamine receptor D2 Dopamine receptor Similarity Comparative molecular field analysis method Mammalia Rodentia Vertebrata
- Keyword (es)
- Agonista Animal Efecto estérico Efecto electroestático Homología Línea celular establecida Modelo 3 dimensiones Modelo molecular Modelización Medicamento Predicción Rata Relación estructura actividad Receptor dopaminérgico D1 Receptor dopaminérgico D2 Similitud Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2438954
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm9800292 
https://dx.doi.org/10.1021/jm9800292
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