Synthesis and biological evaluation of novel F-18 labeled pyrazolo[1,5-a] pyrimidine derivatives: Potential PET imaging agents for tumor detection
- Author
- JINGLI XU1 ; HANG LIU1 ; MINGXIA ZHAO1 ; CHUANMIN QI1 ; YONGHONG DANG2 ; GUIXIA LI1 ; YONG HE1 ; RUI DING1 ; XIAO WANG1 ; MAN FENG1 ; SHUTING ZHANG1 ; YURONG CHEN1 ; SHILEI LI1
[1] Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China
[2] Department of Nuclear Medicine, PUMC Hospital, Beijing 100730, China - Source
Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 16, pp 4736-4741, 6 p ; ref : 31 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- F-18 labeled PET imaging agents Pyrazolo[1,5-a]pyrimidine derivatives Tumor detection
- Keyword (fr)
- Activité biologique Agent scintigraphique Animal Captation Carboxamide Composé bicyclique Composé nitro Distribution Dérivé de la benzamide Fluor 18 Fluor Isotope Hétérocycle azote angulaire Marquage radioisotopique Nitrile Pharmacocinétique Pyrazolopyrimidine dérivé Sarcome 180 Souris Synthèse chimique Tissu Tomographie par émission de positons Tumeur maligne Voie intraveineuse Biodistribution Pyrazolo[1,5-a]pyrimidine dérivé Cancer Mammalia Rodentia Vertebrata
- Keyword (en)
- Biological activity Scintigraphic agent Animal Uptake Carboxamide Bicyclic compound Nitro compound Distribution Benzamide derivatives Fluorine 18 Fluorine Isotopes Angular nitrogen heterocycle Radiolabelling Nitrile Pharmacokinetics Pyrazolopyrimidine derivatives Sarcoma 180 Mouse Chemical synthesis Tissue Positron emission tomography Malignant tumor Intravenous administration Cancer Mammalia Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Agente centelleográfico Animal Captación Carboxamida Compuesto bicíclico Compuesto nitro Distribución Benzamida derivado Fluor Isótopo Heterociclo nitrógeno angular Marcación radioisotópica Nitrilo Farmacocinética Pyrazolopirimidina derivado Sarcoma 180 Ratón Síntesis química Tejido Tomografía emisión positrones Tumor maligno Vía intravenosa Cáncer Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02T Contrast media. Radiopharmaceuticals
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24480656
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2011.06.072 
https://dx.doi.org/10.1016/j.bmcl.2011.06.072
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