PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel and CMF versus a standard-dosed epirubicin/cyclophosphamide followed by paclitaxel ± darbepoetin alfa in primary breast cancer: results at the time of surgery
- Author
- UNTCH, M1 ; FASCHING, P. A2 ; LIEDTKE, B11 ; SALAT, C12 ; HARBECK, N13 ; MÜLLER, V14 ; SCHMIDT, M15 ; HASMÜLLER, S4 ; LENHARD, M4 ; SCHUSTER, T16 ; NEKLJUDOVA, V17 ; LEBEAU, A18 ; KONECNY, G. E3 ; LOIBL, S17 ; VON MINCKWITZ, G17 ; VON KOCH, F4 ; CONRAD, U5 ; FETT, W6 ; KURZEDER, C7 ; LÜCK, H.-J8 ; STICKELER, E9 ; URBACZYK, H10
[1] Department of Obstetrics and Gynecology, Helios Klinikum Berlin-Buch, Berlin, Germany
[2] Department of Obstetrics and Gynecology, University Hospital Erlangen, Erlangen, Germany
[3] Division of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles, United States
[4] Department of Obstetrics and Gynecology, Ludwig-Maximilians-University Grosshadern, Munich, Germany
[5] Department of Obstetrics and Gynecology, St. Barbara Hospital, Hamm, Germany
[6] Hematologic/Oncologic Clinic, Wuppertal, Germany
[7] University Women's Hospital of Ulm, Ulm, Germany
[8] Department of Obstetrics and Gynecology, Medical University of Hannover, Hannover, Germany
[9] University Women's Hospital of Freiburg, Freiburg, Germany
[10] City Hospital, Kassel, Germany
[11] Department of Obstetrics and Gynecology, Protestant Hospital, Bergisch Gladbach, Germany
[12] Hematologic/ Oncologic Practice München, Germany
[13] Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany
[14] Department of Obstetrics and Gynecology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
[15] University Women's Hospital of Mainz, Mainz, Germany
[16] Institute for Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany
[17] German Breast Group, Neu-Isenburg, Germany
[18] Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Arbeitsgemeinschaft Gynäkologische Onkologie PREPARE investigators - Source
Annals of oncology. 2011, Vol 22, Num 9, pp 1988-1998, 11 p ; ref : 36 ref
- ISSN
- 0923-7534
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Oxford University Press, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- darbepoetin alfa dose-dense chemotherapy dose-intensified chemotherapy neoadjuvant chemotherapy pathological complete response primary breast cancer
- Keyword (fr)
- Anticancéreux Cancer du sein Chimiothérapie Chirurgie Cyclophosphamide Darbépoétine alfa Dose forte Epirubicine Essai clinique phase III Essai clinique Etalon Etude comparative Homme Intensification Norme Paclitaxel Préopératoire Randomisation Traitement néoadjuvant Cancer primitif Agent alkylant Anthracyclines Antimitotique Cancer Dérivé de l'oxazaphosphinane Dérivé du taxane Moutarde à l'azote Pathologie de la glande mammaire Pathologie du sein Traitement Tumeur maligne
- Keyword (en)
- Antineoplastic agent Breast cancer Chemotherapy Surgery Cyclophosphamide Darbepoetin alfa High dose Epirubicin Phase III trial Clinical trial Standard Comparative study Human Intensification Standards Paclitaxel Preoperative Randomization Neoadjuvant treatment Primary cancer Alkylating agent Anthracyclins Antimitotic Cancer Oxazaphosphinane derivatives Taxane derivatives Nitrogen mustard Mammary gland diseases Breast disease Treatment Malignant tumor
- Keyword (es)
- Anticanceroso Cáncer del pecho Quimioterapia Cirugía Ciclofosfamida Darbepoetina alfa Dosis fuerte Epirubicina Ensayo clínico fase III Ensayo clínico Marco Estudio comparativo Hombre Intensificación Norma Paclitaxel Preoperatorio Aleatorización Neocoadyuvante tratamiento Agente alquilante Antraciclinas Antimitótico Cáncer Oxazafosfinano derivado Taxane derivado Mostaza al nitrógeno Glándula mamaria patología Seno patología Tratamiento Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B20 Gynecology. Andrology. Obstetrics / 002B20E Mammary gland diseases / 002B20E02 Tumors
- Discipline
- Gynecology. Andrology. Obstetrics Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24492507
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1093/annonc/mdq709 
https://dx.doi.org/10.1093/annonc/mdq709
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