Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
- Author
- JANG HYUN CHOI1 ; BANKS, Alexander S1 ; MARCIANO, David P3 ; CAMERON, Michael D2 3 4 ; LAZNIK, Dina1 ; JURCZAK, Michael J6 ; SCHÜRER, Stephan C7 ; VIDOVIC, Dusica7 ; SHULMAN, Gerald I6 ; SPIEGELMAN, Bruce M1 ; GRIFFIN, Patrick R2 3 4 ; KAMENECKA, Theodore M2 4 ; BUSBY, Scott A3 ; CHALMERS, Michael J3 ; KUMAR, Naresh3 ; KURUVILLA, Dana S3 ; SHIN, Youseung2 ; YUANJUN HE2 ; BRUNING, John B5
[1] Department of Cancer Biology and Division of Metabolism and Chronic Disease, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States
[2] Translational Research Institute, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, United States
[3] Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, United States
[4] The Scripps Research Molecular Screening Center (SRMSC), The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, United States
[5] Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128, United States
[6] Howard Hughes Medical Institute, Departments of Internal Medicine and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510, United States
[7] Center for Computational Science, University of Miami, Miami, Florida 33136, United States - Source
Nature (London). 2011, Vol 477, Num 7365, pp 477-481, 5 p ; ref : 28 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Efficacité traitement Hypoglycémiant Modèle animal Médicament Pharmacothérapie Phosphorylation Recherche et développement Récepteur PPAR-γ Souris Structure chimique Cyclin dependent kinase 5 Mammalia Rodentia Traitement Vertebrata
- Keyword (en)
- Treatment efficiency Hypoglycemic agent Animal model Drug Pharmacotherapy Phosphorylation Research and development PPAR-γ receptor Mouse Chemical structure Mammalia Rodentia Treatment Vertebrata
- Keyword (es)
- Eficacia tratamiento Hipoglicemiante Modelo animal Medicamento Farmacoterapia Fosforilación Investigación desarrollo Receptor PPAR-γ Ratón Estructura química Mammalia Rodentia Tratamiento Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A03 Pharmaceutical technology. Pharmaceutical industry
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance
- Discipline
- Endocrinopathies General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24523844
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature10383 
https://dx.doi.org/10.1038/nature10383
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