Effect of Polymer Structure on Micelles Formed between siRNA and Cationic Block Copolymer Comprising Thiols and Amidines

Author

JAMES CHRISTIE, R¹ ; MIYATA, Kanjiro^{2 3 4} ; YAMASAKI, Yuichi^{1 3} ; KATAOKA, Kazunori^{1 2 3} ; MATSUMOTO, Yu^{2 5 6} ; NOMOTO, Takahiro⁴ ; MENASCO, Daniel⁷ ; CHUNG LAI, Tzai⁷ ; PENNISI, Matthew¹ ; OSADA, Kensuke^{1 3} ; FUKUSHIMA, Shigeto¹ ; NISHIYAMA, Nobuhiro²
[1] Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Japan
[2] Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Japan
[3] Center for NanoBio Integration, The University of Tokyo, Japan
[4] Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Japan
[5] Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan
[6] Department of Otorhinolaryngology and Head and Neck Surgery, Mitsui Memorial Hospital, Japan
[7] Center for Medical Systems Innovation Summer Internship Program, The University of Tokyo, Japan

Source

Biomacromolecules. 2011, Vol 12, Num 9, pp 3174-3185, 12 p ; ref : 32 ref

ISSN

1525-7797

Scientific domain

Biochemistry, molecular biology, biophysics; Polymers, paint and wood industries

Publisher

American Chemical Society, Washington, DC

Publication country

United States

Document type

Article

Language

English

Keyword (fr)

ARNsi Activité biologique Biodisponibilité Condensation chimique Copolymère biséquencé Copolymère réticulé Disulfure organique Ethylène oxyde copolymère Etude expérimentale Hétérocycle soufre In vitro Lysine copolymère Modification chimique Peptide copolymère Polymère amphiphile Polymère fonctionnel Polymère vecteur Préparation Réticulation Silence expression génique Solution aqueuse Solution micellaire Stabilité chimique Thiol copolymère Thérapie génique Vecteur médicament Lysine dérivé copolymère Morphologie micellaire Polyplexe Réactif Traut

Keyword (en)

siRNA Biological activity Bioavailability Condensation reaction Diblock copolymer Crosslinked copolymer Organic disulfide Ethylene oxide copolymer Experimental study Sulfur heterocycle In vitro Lysine copolymer Chemical modification Aminoacid copolymer Amphiphilic polymer Functional polymer Control release polymer Preparation Crosslinking Gene silencing Aqueous solution Micellar solution Chemical stability Thiol copolymer Gene therapy Drug carrier Polyplex

Keyword (es)

ARNsi Actividad biológica Biodisponibilidad Condensación química Copolímero bisecuencia Copolímero reticulado Disulfuro orgánico Etileno óxido copolímero Estudio experimental Heterociclo azufre In vitro Lisina copolímero Modificación química Péptido copolímero Polímero amfifilo Polímero funcional Polímero vector Preparación Reticulación Silencio expresión genética Solución acuosa Solución micelar Estabilidad química Tiol copolímero Terapia génica Vector medicamento

Classification

Pascal

001 Exact sciences and technology / 001D Applied sciences / 001D09 Physicochemistry of polymers / 001D09F Synthetic biopolymers / 001D09F02 Aminoacid polymers

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A03 Pharmaceutical technology. Pharmaceutical industry

Discipline

General pharmacology Physical chemistry of polymers

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

24524564

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS