A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Author

MATMATI, Mourad^{1 2} ; JACQUES, Peggy³ ; YUANYUAN CHU⁶ ; BOON, Louis⁷ ; STAELENS, Steven^{8 9} ; MATTHYS, Patrick⁵ ; LAMBRECHT, Bart N⁴ ; SCHMIDT-SUPPRIAN, Marc⁶ ; PASPARAKIS, Manolis¹⁰ ; ELEWAUT, Dirk³ ; BEYAERT, Rudi^{1 2} ; LOO, Geert Van^{1 2} ; MAELFAIT, Jonathan^{1 2} ; VERHEUGEN, Eveline³ ; KOOL, Mirjam^{1 4} ; SZE, Mozes^{1 2} ; GEBOES, Lies⁵ ; LOUAGIE, Els³ ; MC GUIRE, Conor^{1 2} ; VEREECKE, Lars^{1 2}
[1] Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium
[2] Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
[3] Department of Rheumatology, Laboratory for Molecular Immunology and Inflammation, Ghent University Hospital, Ghent, Belgium
[4] Department of Respiratory Diseases, Laboratory of Immunoregulation and Mucosal Immunology, Ghent University Hospital, Ghent, Belgium
[5] Rega Institute, Leuven University, Leuven, Belgium
[6] Max Planck Institute of Biochemistry, Martinsried, Germany
[7] Bioceros, Utrecht, Netherlands
[8] Medical Image and Signal Processing, Ghent University and Institute for Broadband Technology, Ghent, Belgium
[9] Molecular Imaging Center Antwerp, Antwerp University, Antwerp, Belgium
[10] Institute for Genetics, Centre for Molecular Medicine (CMMC) and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

Source

Nature genetics. 2011, Vol 43, Num 9, pp 908-912, 5 p ; ref : 27 ref

CODEN

NGENEC

ISSN

1061-4036

Scientific domain

Genetics

Publisher

Nature Publishing Group, New York, NY

Publication country

United States

Document type

Article

Language

English

Keyword (fr)

Cellule myéloïde Chronique Déficit Polyarthrite rhumatoïde Immunopathologie Maladie autoimmune Pathologie du système ostéoarticulaire Rhumatisme inflammatoire

Keyword (en)

Myeloid cell Chronic Deficiency Rheumatoid arthritis Immunopathology Autoimmune disease Diseases of the osteoarticular system Inflammatory joint disease

Keyword (es)

Célula mieloide Crónico Déficiencia Poliartritis reumatoidea Inmunopatología Enfermedad autoinmune Sistema osteoarticular patología Reumatismo inflamatorio

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15D Inflammatory joint diseases

Discipline

Eukaryotes genetics. Biological and molecular evolution Osteoarticular pathology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

24566418

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS