Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors
- Author
- HOU, Ya-Ping; JUAN SUN; PANG, Zhong-Hua; LV, Peng-Cheng; LI, Dong-Dong; LI YAN; ZHANG, Hong-Jia; XI ZHENG, Emily; JING ZHAO; ZHU, Hai-Liang
[1] State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China
[2] Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, United States - Source
Bioorganic & medicinal chemistry. 2011, Vol 19, Num 20, pp 5948-5954, 7 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Antitumor activity Auto Dock Benzodioxan MetAP2 Triazole
- Keyword (fr)
- Anticancéreux Apoptose Cellule tumorale Dérivé du triazole Fluor Composé organique Foie Homme Hépatocyte In vitro Inhibiteur enzyme Lignée cellulaire Methionyl aminopeptidase Modèle moléculaire Modélisation Mort cellulaire Relation structure activité Site fixation Synthèse chimique 1,2,4-Triazole dérivé 1,2,4-Triazole(3-[2,3-dihydro-1,4-benzodioxin-6-yl]-5-[2-fluorobenzylsulfanyl]-4-phényl) 1,4-Benzodioxine dérivé Benzodioxane dérivé Lignée HEPG2 Aminopeptidases Dérivé d'azole Enzyme Hydrolases Peptidases
- Keyword (en)
- Antineoplastic agent Apoptosis Tumor cell Triazole derivatives Fluorine Organic compounds Liver Human Hepatocyte In vitro Enzyme inhibitor Cell line Methionyl aminopeptidase Molecular model Modeling Cell death Structure activity relation Binding site Chemical synthesis Aminopeptidases Azole derivatives Enzyme Hydrolases Peptidases
- Keyword (es)
- Anticanceroso Apoptosis Célula tumoral Triazol derivado Fluor Compuesto orgánico Hígado Hombre Hepatocito In vitro Inhibidor enzima Línea celular Methionyl aminopeptidase Modelo molecular Modelización Muerte celular Relación estructura actividad Sitio fijación Síntesis química Aminopeptidases Azol derivado Enzima Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 24594783
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2011.08.063 
https://dx.doi.org/10.1016/j.bmc.2011.08.063
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