Conformationally constrained analogues of diacylglycerol. 13. Protein kinase C ligands based on templates derived from 2,3-dideoxy-L-erythro(threo)-hexono-1,4-lactone and 2-deoxyapiolactone
- Author
- LEE, J1 ; LEWIN, N. E1 ; ACS, P1 ; BLUMBERG, P. M1 ; MARQUEZ, V. E1
[1] Laboratories of Medicinal Chemistry and Cellular and of Cellular Carcinogenesis and Tumor Promotion, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States - Source
Journal of medicinal chemistry (Print). 1996, Vol 39, Num 25, pp 4912-4919 ; ref : 23 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide aldonique Affinité Diastéréoisomère Encombrement stérique Epimère Fixation biologique Hétérocycle oxygène In vitro Isozyme Lactone Ligand Protein kinase C Relation structure activité Récepteur biologique Synthèse chimique Furane-3-acétique acide(3-[2-hydroxyéthyl]-5-oxo-perhydro) ester myristyle Furane-3-acétique acide(3-hydroxyméthyl-5-oxo-perhydro) ester myristyle Hexonique acide(2,3-didésoxy-5-O-myristoyl)-1(4)-lactone Enzyme Transferases
- Keyword (en)
- Aldonic acid Affinity Diastereomer Steric hindrance Epimer Biological fixation Oxygen heterocycle In vitro Isozyme Lactone Ligand Protein kinase C Structure activity relation Biological receptor Chemical synthesis Enzyme Transferases
- Keyword (es)
- Acido aldónico Afinidad Diasteréomero Embarazo estérico Epímero Fijación biológica Heterociclo oxígeno In vitro Isozima Lactona Ligando Protein kinase C Relación estructura actividad Receptor biológico Síntesis química Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2509139
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm960525v 
https://dx.doi.org/10.1021/jm960525v
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