Natural Product Libraries to Accelerate the High-Throughput Discovery of Therapeutic Leads
- Author
- JOHNSON, Tyler A1 2 ; SOHN, Johann1 ; BRAY, Walter M3 ; GASSNER, Nadine C3 ; SHEN, Young Y6 ; LOKEY, R. Scott2 3 ; MCKERROW, James H5 ; BOUNDY-MILLS, Kyria7 ; NUKANTO, Arif8 ; KANTI, Atit8 ; JULISTIONO, Heddy8 ; KARDONO, Leonardus B. S9 ; INMAN, Wayne D2 ; BJELDANES, Leonard F1 ; CREWS, Phillip2 ; ESTEE, Samarkand A2 ; LOVERIDGE, Steven T2 ; VERVOORT, Helene C2 ; TENNEY, Karen2 ; JUNKE LIU6 ; KEAN-HOOI ANG, Kenny4 ; RATNAM, Joseline4
[1] Department of Nutritional Sciences & Toxicology, University of California, Berkeley, California 94720, United States
[2] Department of Chemistry & Biochemistry, University of California, Santa Cruz, California 95064, United States
[3] UCSC Chemical Screening Center, University of California, Santa Cruz, California 95064, United States
[4] Sandler Center for Drug Discovery, University of California, San Francisco, California 94143, United States
[5] Small Molecule Discovery Center, University of California, San Francisco, California 94158, United States
[6] Natural Product Lead Discovery, Eisai Inc., Andover, Massachusetts 01810, United States
[7] Phaff Yeast Culture Collection, Food Science and Technology, University of California Davis, Davis, California 95616, United States
[8] Research Center for Biology, Indonesian Institute of Science (LIPI), Cibinong, 16911, Indonesia
[9] Research Center for Chemistry, Indonesian Institute of Science (LIPI), Serpong, Tangerang 15310, Indonesia - Source
Journal of natural products (Print). 2011, Vol 74, Num 12, pp 2545-2555, 11 p ; ref : 53 ref
- CODEN
- JNPRDF
- ISSN
- 0163-3864
- Scientific domain
- Pharmacology drugs
- Publisher
- American Society of Pharmacognosy, Northbrook, IL
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Analyse chimique Analyse qualitative Analyse structurale Anticancéreux Antiparasitaire Antiprotozoaire Cellule tumorale Chimiothèque Chromatographie HPLC Composé naturel Criblage haut débit Cytotoxicité Détecteur UV Détecteur évaporatif diffusion lumière In vitro Lignée cellulaire Milieu marin Métabolite Méthode couplée Origine animale Pharmacognosie Porifera Région Indopacifique Sesquiterpène Spectrométrie masse Terpénoïde Trypanosoma brucei Aignopsane dérivé Aignopsanoique acide B Apo latrunculine T Cacospongia mycofijiensis Fijianolide A(20-méthoxy) Thiazol-2-one dérivé Invertebrata Kinetoplastida Protozoa
- Keyword (en)
- Biological activity Chemical analysis Qualitative analysis Structural analysis Antineoplastic agent Parasiticide Antiprotozoal agent Tumor cell Chemical compound library HPLC chromatography Natural compound High throughput screening Cytotoxicity Ultraviolet detector Evaporative light scattering detector In vitro Cell line Marine environment Metabolite Coupled method Animal origin Pharmacognosy Porifera Indopacific Region Sesquiterpenes Mass spectrometry Terpenoid Trypanosoma brucei Invertebrata Kinetoplastida Protozoa
- Keyword (es)
- Actividad biológica Análisis químico Análisis cualitativo Análisis estructural Anticanceroso Antiparasitario Antiprotozoario Célula tumoral Quimioteca Cromatografía HPLC Compuesto natural Cribado alta productividad Citotoxicidad Detector UV Detector evaporativo dispersión luz In vitro Línea celular Medio marino Metabolito Método acoplado Origen animal Farmacognosia Porifera Región Indopacífica Sesquiterpeno Espectrometría masa Terpenoide Trypanosoma brucei Invertebrata Kinetoplastida Protozoa
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A04 Pharmacognosy. Homeopathy. Health food
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25339359
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/np200673b 
https://dx.doi.org/10.1021/np200673b
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