Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- Author
- METALLO, Christian M1 ; GAMEIRO, Paulo A1 2 3 4 ; KELLEHER, Joanne K1 ; VANDER HEIDEN, Matthew G5 6 8 ; ILIOPOULOS, Othon3 4 ; STEPHANOPOULOS, Gregory1 ; BELL, Eric L5 ; MATTAINI, Katherine R5 6 ; JUANJUAN YANG3 4 ; HILLER, Karsten1 ; JEWELL, Christopher M6 ; JOHNSON, Zachary R6 ; IRVINE, Darrell J6 7 ; GUARENTE, Leonard5
[1] Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
[2] Department of Life Sciences, University of Coimbra, 3004-517 Coimbra, Portugal
[3] Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, United States
[4] Massachusetts General Hospital Center for Cancer Research, Charlestown, Massachusetts 02129, United States
[5] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
[6] Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
[7] Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States
[8] Dana-Farber Cancer Institute, Boston, Massachusetts 02115, United States - Source
Nature (London). 2012, Vol 481, Num 7381, pp 380-384, 5 p ; ref : 30 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Biosynthèse Glutamine Hypoxie In vitro Isocitrate dehydrogenase (NADP+) Lipide Métabolisme Aminoacide Enzyme Oxidoreductases Oxygène
- Keyword (en)
- Biosynthesis Glutamine Hypoxia In vitro Isocitrate dehydrogenase (NADP+) Lipids Metabolism Aminoacid Enzyme Oxidoreductases Oxygen
- Keyword (es)
- Biosíntesis Glutamina Hipoxia In vitro Isocitrate dehydrogenase (NADP+) Lípido Metabolismo Aminoácido Enzima Oxidoreductases Oxígeno
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04H Cell physiology / 002A04H01 Cell metabolism, cell oxidation
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A16 Vertebrates: anatomy and physiology, studies on body, several organs or systems / 002A16D Metabolisms and neurohumoral controls / 002A16D04 Lipids. Glycolipids
- Discipline
- Molecular and cell biology Vertebrates : anatomy and physiology, studies on body, several organs or systems
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25380630
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature10602 
https://dx.doi.org/10.1038/nature10602
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