Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activity
- Author
- PENNINGTON, Lewis D1 ; CROGHAN, Michael D1 ; MCELVAIN, Michele3 ; YANG XU4 ; XUXIA ZHANG5 ; FIORINO, Michael5 ; HORNER, Michelle6 ; MORRISON, Henry G7 ; ARNETT, Heather A5 ; FOTSCH, Christopher1 ; TASKER, Andrew S1 ; MIN WONG5 ; SHAM, Kelvin K. C1 ; CEE, Victor J1 ; PICKRELL, Alexander J1 ; HARRINGTON, Paul E1 ; FROHN, Michael J1 ; LANMAN, Brian A1 ; REED, Anthony B1 ; LEE, Matthew R2 ; HAN XU3
[1] Medicinal Chemistry, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, United States
[2] Molecular Structure, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, United States
[3] HTS and Molecular Pharmacology, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, United States
[4] Pharmacokinetics and Drug Metabolism, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, United States
[5] Inflammation Research, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, United States
[6] Toxicology, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, United States
[7] Pharmaceutics, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 1, pp 527-531, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Immunosuppression Multiple sclerosis N-scan SAR Physicochemical properties Sphingosine-1-phosphate-1 receptor agonist
- Keyword (fr)
- Agoniste Dérivé de la quinolone Dérivé de la quinoléine Immunodépression In vitro In vivo Propriété physicochimique Relation structure activité Récepteur biologique Sclérose en plaques Sphingosine-1-phosphate Récepteur sphingosine 1 phosphate Maladie inflammatoire Pathologie du système nerveux central Pathologie du système nerveux
- Keyword (en)
- Agonist Quinolone derivatives Quinoline derivatives Immunosuppression In vitro In vivo Physicochemical properties Structure activity relation Biological receptor Multiple sclerosis Sphingosine-1-phosphate Inflammatory disease Central nervous system disease Nervous system diseases
- Keyword (es)
- Agonista Quinolone derivado Quinolina derivado Inmunodepresión In vitro In vivo Propiedad fisicoquímica Relación estructura actividad Receptor biológico Esclerosis en placa Esfingosina-1-fosfato Enfermedad inflamatoria Sistema nervosio central patología Sistema nervioso patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25413365
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2011.10.085 
https://dx.doi.org/10.1016/j.bmcl.2011.10.085
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