Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
- Author
- HAGA, Kazuko1 ; KRUSE, Andrew C2 ; KOBAYASHI, Takuya3 4 7 ; ASADA, Hidetsugu3 4 ; YURUGI-KOBAYASHI, Takami3 4 ; SHIROISHI, Mitsunori4 5 ; CHENG ZHANG2 ; WEIS, William I2 6 ; OKADA, Tetsuji1 ; KOBILKA, Brian K2 ; HAGA, Tatsuya1
[1] Department of Life Science, Faculty of Science, Gakushuin University, Mejiro 1-5-1, Tokyo 171-8588, Japan
[2] Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, United States
[3] Departmentof Medical Chemistry and Cell Biology, Kyoto University Faculty of Medicine, Konoe-cho, Yoshdida, Sakyo-Ku, Kyoto 606-8501, Japan
[4] Human Receptor Crystallography Project, ERATO, Japan Science and Technology Agency, Konoe-cho, Yoshida, Sakyo-Ku, Kyoto 606-8501, Japan
[5] Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
[6] Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive, Stanford, California 94305, United States
[7] Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), Kyoto University Faculty of Medicine, Kyoto 606-8501, Japan - Source
Nature (London). 2012, Vol 482, Num 7386, pp 547-551, 5 p ; ref : 30 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acétylcholine Antagoniste Canal ionique Contrôle cardiovasculaire Homme Potassium Protéine G Récepteur biologique Récepteur muscarinique M2 Récepteur muscarinique Système nerveux autonome Système nerveux central Système nerveux parasympathique Neurotransmetteur Récepteur cholinergique
- Keyword (en)
- Acetylcholine Antagonist Ionic channel Cardiovascular control Human Potassium G protein Biological receptor M2 Muscarinic receptor Muscarinic receptor Autonomic nervous system Central nervous system Parasympathetic nervous system Neurotransmitter Cholinergic receptor
- Keyword (es)
- Acetilcolina Antagonista Canal iónico Control cardiovascular Hombre Potasio Proteína G Receptor biológico Receptor muscarínico M2 Receptor muscarínico Sistema nervioso autónomo Sistema nervioso central Sistema nervioso parasimpático Neurotransmisor Receptor colinérgico
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A25 Vertebrates: nervous system and sense organs / 002A25G Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ
- Discipline
- Vertebrates : nervous system and sense organs
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25527642
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature10753 
https://dx.doi.org/10.1038/nature10753
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