Effect of linker variation on the stability, potency, and efficacy of carcinoma-reactive BR64-doxorubicin immunoconjugates
- Author
- TRAIL, P. A1 ; WILLNER, D2 ; BRASLAWSKY, G. R; BROWN, J; HOFSTEAD, S. J2 ; GREENFIELD, R. S; FIRESTONE, R. A2 ; MOSURE, K2 ; KADOW, K. F; YANG, M. B1 ; HELLSTRÖM, K. E3 ; HELLSTRÖM, I3 ; KNIPE, J2 ; HENDERSON, A. J1 ; LASCH, S. J1 ; ZOECKLER, M. E2 ; TRAILSMITH, M. D; DOYLE, T. W2 ; KING, H. D2 ; CASAZZA, A. M1
[1] Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, United States
[2] Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, United States
[3] Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121, United States - Source
Cancer research (Baltimore). 1997, Vol 57, Num 1, pp 100-105 ; ref : 36 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Anthracyclines Anticancéreux Anticorps monoclonal Antigène Cale espacement Cible Conjugaison Doxorubicine Fixation chimique Immunoconjugué In vitro In vivo Liaison disulfure Pharmacocinétique Relation structure activité Souris Stabilité Sulfure organique Système Lewis Tumeur maligne Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Anthracyclins Antineoplastic agent Monoclonal antibody Antigen Spacer Target Conjugation Doxorubicin Chemical uptake Immunoconjugate In vitro In vivo Disulfide bond Pharmacokinetics Structure activity relation Mouse Stability Organic sulfide Lewis system Malignant tumor Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Antraciclinas Anticanceroso Anticuerpo monoclonal Antígeno Calce espaciamiento Blanco Conjugación Doxorubicina Fijación química Inmunoconjugado In vitro In vivo Enlace disulfuro Farmacocinética Relación estructura actividad Ratón Estabilidad Sulfuro orgánico Sistema Lewis Tumor maligno Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2566543
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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