Ran Is a Potential Therapeutic Target for Cancer Cells with Molecular Changes Associated with Activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK Pathways
- Author
- YUEN, Hiu-Fung1 ; CHAN, Ka-Kui1 ; RUDLAND, Philip S2 ; EL-TANANI, Mohamed1 ; GRILLS, Claire1 ; MURRAY, James T1 ; PLATT-HIGGINS, Angela2 ; ELDIN, Osama Sharaf3 ; O'BYRNE, Ken4 ; JANNE, Pasi5 ; FENNELL, Dean A1 ; JOHNSTON, Patrick G1
[1] Center for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, United Kingdom
[2] Cancer and Polio Research Fund Laboratories, School of Biological Sciences, University of Liverpool, Liver-pool, United Kingdom
[3] Pathology Department, St. Vincent's Hospital, Dublin, Ireland
[4] St James's Hospital, James St, Dublin 8, Ireland
[5] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States - Source
Clinical cancer research (Print). 2012, Vol 18, Num 2, pp 380-391, 12 p ; ref : 47 ref
- CODEN
- CCREF4
- ISSN
- 1078-0432
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- 1-Phosphatidylinositol 3-kinase Activation Akt protein kinase Cellule cible Cellule tumorale Ciblage Extracellular signal-regulated protein kinase Gène onc cellulaire Gène ras Mitogen-activated protein kinase Protooncogène Thérapeutique ciblée Traitement Enzyme Régulation Transferases
- Keyword (en)
- 1-Phosphatidylinositol 3-kinase Activation Akt protein kinase Target cell Tumor cell Targeting Extracellular signal-regulated protein kinase C-Onc gene Ras gene Mitogen-activated protein kinase Protooncogene Targeted therapy Treatment Enzyme Regulation(control) Transferases
- Keyword (es)
- 1-Phosphatidylinositol 3-kinase Activación Akt protein kinase Célula blanco Célula tumoral Blancado Extracellular signal-regulated protein kinase Gen onc celular Gen ras Mitogen-activated protein kinase Protooncogen Terapéutica dirigida Tratamiento Enzima Regulación Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25772327
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1158/1078-0432.CCR-11-2035 
https://dx.doi.org/10.1158/1078-0432.CCR-11-2035
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