Sorafenib (BAY 43-9006) in Hepatocellular Carcinoma Patients: From Discovery to Clinical Development : Targeting Tumor Angiogenesis: An Update
- Author
- RANIERI, G1 ; GADALETA-CALDAROLA, G1 ; GOFFREDO, V1 ; PATRUNO, R3 ; MANGIA, A2 ; RIZZO, A3 ; SCIORSCI, R. L3 ; GADALETA, C. D1
[1] Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Centre Giovanni Paolo II, Bari, Italy
[2] Clinical Experimental Oncology Laboratory, National Cancer Centre 'Giovanni Paolo II'., Bari, Italy
[3] Department of Animal Production, Faculty of Veterinary Medicine, University of Bari, Strada p.le per Casamassima, km 3, 70010 -Valenzano (Bari), Italy - Source
Current medicinal chemistry. 2012, Vol 19, Num 7, pp 938-944, 7 p ; ref : 100 ref
- ISSN
- 0929-8673
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Bentham, Oak Park, IL
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- Bi-aryl urea BAY 43-9006 HCC RAS/RAF signaling pathway TACE VEGFR sorafenib tyrosine kinase angiogenesis
- Keyword (fr)
- Anticancéreux Article synthèse Carcinome hépatocellulaire Chimiothérapie Essai clinique Facteur angiogène Facteur croissance dérivé thrombocyte Facteur croissance endothélium vasculaire Homme In vitro In vivo Inhibiteur enzyme Inhibiteur multikinase Non-specific serine/threonine protein kinase Pharmacocinétique Relation structure activité Récepteur facteur croissance Sorafénib Transduction signal Urées Voie orale BAY 43 9006 Inhibiteur kinase raf PDGFR Receptor protein-tyrosine kinase VEGFR Cancer Enzyme Pathologie de l'appareil digestif Pathologie du foie Traitement Transferases Tumeur maligne
- Keyword (en)
- Antineoplastic agent Review Hepatocellular carcinoma Chemotherapy Clinical trial Angiogenic factor Platelet derived growth factor Vascular endothelium growth factor Human In vitro In vivo Enzyme inhibitor Multikinase inhibitor Non-specific serine/threonine protein kinase Pharmacokinetics Structure activity relation Growth factor receptor Sorafenib Signal transduction Ureas Oral administration Receptor protein-tyrosine kinase Cancer Enzyme Digestive diseases Hepatic disease Treatment Transferases Malignant tumor
- Keyword (es)
- Anticanceroso Artículo síntesis Carcinoma hepatocelular Quimioterapia Ensayo clínico Factor angiógeno Factor crecimiento derivado plaqueta Factor crecimiento endotelio vascular Hombre In vitro In vivo Inhibidor enzima inhibidor multicinasa Non-specific serine/threonine protein kinase Farmacocinética Relación estructura actividad Receptor factor crecimiento Sorafenib Transducción señal Ureas Vía oral Receptor protein-tyrosine kinase Cáncer Enzima Aparato digestivo patología Hígado patología Tratamiento Transferases Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25862907
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.2174/092986712799320736 
https://dx.doi.org/10.2174/092986712799320736
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