Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2
- Author
- EL-SAYED, Magda A.-A1 ; ABDEL-AZIZ, Naglaa I2 ; ABDEL-AZIZ, Alaa A.-M2 3 ; EL-AZAB, Adel S3 4 ; ELTAHIR, Kamal E. H5
[1] Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt
[2] Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt
[3] Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
[4] Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt
[5] Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia - Source
Bioorganic & medicinal chemistry. 2012, Vol 20, Num 10, pp 3306-3316, 11 p ; ref : 44 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Anti-inflammatory COX-2 inhibitors Molecular modeling Pyrazole Pyrazoline Synthesis
- Keyword (fr)
- Activité biologique Antiinflammatoire non stéroïde Cyclooxygenase 2 Dérivé du pyrazole Inhibiteur cyclooxygenase 2 Inhibiteur enzyme Modèle moléculaire Modélisation Pyrazole Synthèse chimique Sélectivité Pyrazoline dérivé Enzyme Oxidoreductases
- Keyword (en)
- Biological activity Non steroidal antiinflammatory agent Cyclooxygenase 2 Pyrazole derivatives Cyclooxygenase 2 inhibitor Enzyme inhibitor Molecular model Modeling Pyrazole Chemical synthesis Selectivity Enzyme Oxidoreductases
- Keyword (es)
- Actividad biológica Antiinflamatorio no esteroide Cyclooxygenase 2 Pirazol derivado Inhibidor cyclooxygenase 2 Inhibidor enzima Modelo molecular Modelización Pirazol Síntesis química Selectividad Enzima Oxidoreductases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 25918137
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2012.03.044 
https://dx.doi.org/10.1016/j.bmc.2012.03.044
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