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A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

WAALER, Jo1 ; MACHON, Ondrej1 6 ; GRADL, Dietmar7 ; VORONKOV, Andrey1 ; VON FRIES, Jens Peter8 ; KRAUSS, Stefan1 ; TUMOVA, Lucie6 ; DINH, Huyen1 ; KORINEK, Vladimir6 ; RAY WILSON, Steven2 ; ERIK PAULSEN, Jan3 ; PEDERSEN, Nina Marie4 ; EIDE, Tor J5 ; MACHONOVA, Olga1 6
[1] Oslo University Hospital, SFI-CAST Biomedical Innovation Center, Unit for Cell Signaling, Forskningsparken, Gaustadalleen and Center for Molecular Biology and Neuroscience, Norway
[2] Department of Chemistry, University of Oslo, Norway
[3] Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology, Norway
[4] Institute for Cancer Research, Department of Biochemistry, The Norwegian Radium Hospital, Stem Cell Innovation Centre, Norway
[5] Department of Pathology, Rikshospitalet, Oslo University Hospital, Oslo, Norway
[6] Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic
[7] KIT (Karlsruhe Institute of Technology) Zoological Institute, Cell and Developmental Biology, Karlsruhe, Germany
[8] Leibniz-Institut Für Molekulare Pharmakologie, FMP, Berlin, Germany

Cancer research (Chicago, Ill.). 2012, Vol 72, Num 11, pp 2822-2832, 11 p ; ref : 50 ref

Scientific domain
Medical oncology; Pharmacology drugs
American Association for Cancer Research, Philadelphia, PA
Publication country
United States
Document type
Keyword (fr)
Animal Cancer du côlon Carcinome du côlon Cellule Croissance tumorale Gène suppresseur tumeur In vitro Inhibiteur Mutation conditionnelle Souris Transduction signal Tumeur maligne Gène APC Signalisation cellulaire Cancer Mammalia Pathologie de l'appareil digestif Pathologie de l'intestin Pathologie du côlon Rodentia Vertebrata
Keyword (en)
Animal Colon cancer Colon carcinoma Cell Tumor growth Tumor suppressor gene In vitro Inhibitor Conditional mutation Mouse Signal transduction Malignant tumor APC Gene Cell signaling Cancer Mammalia Digestive diseases Intestinal disease Colonic disease Rodentia Vertebrata
Keyword (es)
Animal Cáncer del colon Carcinoma del colón Célula Crecimiento tumoral Gen supresor tumor In vitro Inhibidor Mutación condicional Ratón Transducción señal Tumor maligno Gen APC Cáncer Mammalia Aparato digestivo patología Intestino patología Colón patología Rodentia Vertebrata
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents

002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors

002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B01 Tumors

Gastroenterology. Liver. Pancreas. Abdomen Pharmacological treatments Tumours
INIST identifier

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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