Conversion of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase
- Author
- MENDEL, D. B1 ; CIHLAR, T1 ; MOON, K1 ; CHEN, M. S1
[1] Gilead Sciences, Inc., Foster City, California, United States - Source
Antimicrobial agents and chemotherapy. 1997, Vol 41, Num 3, pp 641-646 ; ref : 28 ref
- CODEN
- AACHAX
- ISSN
- 0066-4804
- Scientific domain
- Microbiology, infectious diseases; Pharmacology drugs
- Publisher
- American Society for Microbiology, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- 2',3'-Cyclic-nucleotide 3'-phosphodiesterase Activité enzymatique Antiinfectieux Antiviral Appareil digestif Biotransformation Cidofovir Culture primaire Foie Homme Hydrolyse In vitro Promédicament Enzyme Esterases Hydrolases Phosphoric diester hydrolases
- Keyword (en)
- 2',3'-Cyclic-nucleotide 3'-phosphodiesterase Enzymatic activity Antiinfectious Antiviral Digestive system Biotransformation Cidofovir Primary culture Liver Human Hydrolysis In vitro Prodrug Enzyme Esterases Hydrolases Phosphoric diester hydrolases
- Keyword (es)
- 2',3'-Cyclic-nucleotide 3'-phosphodiesterase Actividad enzimática Antiinfeccioso Antiviral Aparato digestivo Biotransformación Cidofovir Cultivo primario Hígado Hombre Hidrólisis In vitro Promedicamento Enzima Esterases Hydrolases Phosphoric diester hydrolases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2594999
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1128/AAC.41.3.641 
https://dx.doi.org/10.1128/AAC.41.3.641
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