Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
- Author
- FUJIMOTO, Akihiro1 ; TOTOKI, Yasushi2 ; ARAI, Yasuhito2 ; TAKAHASHI, Hiroyuki2 ; SHIRAKIHARA, Takuya2 ; NAGASAKI, Masao3 ; SHIBUYA, Tetsuo3 ; NAKANO, Kaoru1 ; WATANABE-MAKINO, Kumiko1 ; TANAKA, Hiroko3 ; NAKAMURA, Hiromi2 ; KUSUDA, Jun4 ; ABE, Tetsuo1 ; OJIMA, Hidenori5 ; SHIMADA, Kazuaki6 ; OKUSAKA, Takuji7 ; UENO, Masaki8 ; SHIGEKAWA, Yoshinobu8 ; KAWAKAMI, Yoshiiku9 ; ARIHIRO, Koji10 ; OHDAN, Hideki11 ; GOTOH, Kunihito12 ; ISHIKAWA, Osamu12 ; BOROEVICH, Keith A1 ; ARIIZUMI, Shun-Ichi13 ; YAMAMOTO, Masakazu13 ; YAMADA, Terumasa12 ; CHAYAMA, Kazuaki1 9 ; KOSUGE, Tomoo6 ; YAMAUE, Hiroki8 ; KAMATANI, Naoyuki1 ; MIYANO, Satoru3 ; NAKAGAMA, Hitoshi14 5 ; NAKAMURA, Yusuke1 15 ; HOSODA, Fumie2 ; TSUNODA, Tatsuhiko1 ; SHIBATA, Tatsuhiro2 ; NAKAGAWA, Hidewaki1 ; NGUYEN, Ha Hai1 ; AOKI, Masayuki1 ; HOSONO, Naoya1 ; KUBO, Michiaki1 ; MIYA, Fuyuki1
[1] Center for Genomic Medicine, RIKEN, Yokohama, Japan
[2] Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan
[3] Laboratory of DNA Informatics Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
[4] National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
[5] Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
[6] Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
[7] Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
[8] Department of Gastroenterological Surgery, Wakayama Medical University, Wakayama, Japan
[9] Department of Medicine & Molecular Science, Hiroshima University School of Medicine, Hiroshima, Japan
[10] Department of Gastroenterological Surgery, Hiroshima University School of Medicine, Hiroshima, Japan
[11] Department of Anatomical Pathology, Hiroshima University School of Medicine, Hiroshima, Japan
[12] Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
[13] Department of Gastroenterological Surgery, Tokyo Women's Medical University, Tokyo, Japan
[14] Division of Cancer Development System, National Cancer Center Research Institute, Tokyo, Japan
[15] Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan - Source
Nature genetics. 2012, Vol 44, Num 7, pp 760-764, 5 p ; ref : 21 ref
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cancer du foie Chromatine Chromosome Génome Identification Mutation Récidivant Séquençage Cancer Pathologie de l'appareil digestif Pathologie du foie Tumeur maligne
- Keyword (en)
- Liver cancer Chromatin Chromosome Genome Identification Mutation Recurrent Sequencing Cancer Digestive diseases Hepatic disease Malignant tumor
- Keyword (es)
- Cáncer del hígado Cromatina Cromosoma Genoma Identificación Mutación Recidivante Sequencing Cáncer Aparato digestivo patología Hígado patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04C Molecular genetics / 002A04C03 Chromatin. Chromosome
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13C Liver. Biliary tract. Portal circulation. Exocrine pancreas / 002B13C01 Tumors
- Discipline
- Eukaryotes genetics. Biological and molecular evolution Gastroenterology. Liver. Pancreas. Abdomen Molecular and cell biology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26117373
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng.2291 
https://dx.doi.org/10.1038/ng.2291
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arXiv access
