Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
- Author
- ZHENFENG ZHANG1 2 3 ; JAE CHEOL LEE4 ; YUN JUNG CHOI8 ; CHOI, Chang-Min4 8 ; KIM, Sang-We4 ; SE JIN JANG9 ; YOUNG SOO PARK9 ; WOO SUNG KIM8 ; DAE HO LEE4 ; LEE, Jung-Shin4 ; MILLER, Vincent A10 ; ARCILA, Maria11 ; LUPING LIN5 ; LADANYI, Marc11 12 ; MOONSAMY, Philicia12 ; SAWYERS, Charles12 ; BOGGON, Titus J13 ; MA, Patrick C14 ; COSTA, Carlota15 16 ; TARON, Miquel15 16 ; ROSELL, Rafael15 16 ; HALMOS, Balazs3 ; BIVONA, Treverg12 5 ; OLIVAS, Victor5 ; AU, Valerie3 ; LAFRAMBOISE, Thomas6 ; ABDEL-RAHMAN, Mohamed2 ; XIAOQI WANG3 ; LEVINE, Alan D1 7 ; JIN KYUNG RHO8
[1] Department of Pathology, Case Western Reserve University School of Medicine, University Hospitals―Case Medical Center and Ireland Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
[2] Division of Hematology/Oncology, Case Western Reserve University School of Medicine, University Hospitals― Case Medical Center and Ireland Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
[3] Division of Hematology/Oncology, Columbia University Medical Center, New York, New York, United States
[4] Department of Oncology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea, Republic of
[5] Division of Hematology/Oncology, Helen Diller Comprehensive Cancer Center, University of California, San Francisco, California, United States
[6] Department of Genetics, Case Western Reserve University School of Medicine, University Hospitals―Case Medical Center and Ireland Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
[7] Division of Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, University Hospitals―Case Medical Center and Ireland Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
[8] Department of Pulmonary and Critical Care Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea, Republic of
[9] Department of Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea, Republic of
[10] Thoracic Medical Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States
[11] Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States
[12] Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States
[13] Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States
[14] Aerodigestive Oncology Translational Research, Translational Hematology and Oncology Research (THOR), Cleveland Clinic Taussig Cancer Institute and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, United States
[15] Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Barcelona, Spain
[16] Pangaea Biotech, USP Dexeus University Institute, Barcelona, Spain - Source
Nature genetics. 2012, Vol 44, Num 8, pp 852-860, 9 p ; ref : 26 ref
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activation Cancer du poumon Kinase Régulation Résistance Cancer Enzyme Pathologie de l'appareil respiratoire Pathologie des bronches Pathologie des poumons Transferases Tumeur maligne
- Keyword (en)
- Activation Lung cancer Kinase Regulation(control) Resistance Cancer Enzyme Respiratory disease Bronchus disease Lung disease Transferases Malignant tumor
- Keyword (es)
- Activación Cáncer del pulmón Kinase Regulación Resistencia Cáncer Enzima Aparato respiratorio patología Bronquio patología Pulmón patología Transferases Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B11 Pneumology / 002B11A Tumors of the respiratory system and mediastinum
- Discipline
- Eukaryotes genetics. Biological and molecular evolution Pulmonology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26219875
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng.2330 
https://dx.doi.org/10.1038/ng.2330
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arXiv access
