Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- Author
- MORRIS, Andrew P1 ; VOIGHT, Benjamin F2 3 ; PROKOPENKO, Inga1 12 ; HYUN MIN KANG4 ; DINA, Christian13 14 15 ; ESKOE, Tonu16 17 ; FRASER, Ross M18 ; KANONI, Stavroula19 ; KUMAR, Ashish1 ; LAGOU, Vasiliki1 ; LANGENBERG, Claudia20 ; LUAN, Jian'an20 ; TESLOVICH, Tanya M4 ; LINDGREN, Cecilia M1 ; MÜLLER-NURASYID, Martina21 23 ; PECHLIVANIS, Sonali24 ; RAYNER, N. William1 12 ; SCOTT, Laura J4 ; WILTSHIRE, Steven1 ; YENGO, Loic25 ; KINNUNEN, Leena2 ; ROSSIN, Elizabeth J2 5 ; RAYCHAUDHURI, Soumya2 ; FERREIRA, Teresa1 ; JOHNSON, Andrew D; DIMAS, Antigones1 ; LOOS, Ruthj F20 ; VEDANTAM, Sailaja; HAN CHEN; FLOREZ, Jose C5 6 ; FOX, Caroline; LIU, Ching-Ti; RYBIN, Denis; COUPER, David J; SEGRE, Ayellet V2 5 6 ; KAO, Wen Hong L; MAN LI; CORNELIS, Marilyn C; KRAFT, Peter; QI SUN; VAN DAM, Rob M; STRINGHAM, Heather M4 ; CHINES, Peter S; FISCHER, Krista16 ; FONTANILLAS, Pierre2 ; STEINTHORSDOTTIR, Valgerdur7 ; HOLMEN, Oddgeir L5 ; HUNT, Sarah E19 ; JACKSON, Anne U4 ; KONG, Augustine7 ; LAWRENCE, Robert; MEYER, Julia22 ; PERRY, John R. B1 ; PLATOU, Carl G. P; POTTER, Simon19 ; REHNBERG, Emil; STRAWBRIDGE, Rona J8 9 ; KHAN, Hassan10 ; GRALLERT, Harald11 ; MAHAJAN, Anubha1
[1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
[2] B road Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States
[3] Department of Pharmacology, University of Pennsylvania―Perelman School of Medicine, Philadelphia, Pennsylvania, United States
[4] Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States
[5] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States
[6] Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States
[7] CODE Genetics, Reykjavik, Iceland
[8] Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
[9] Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
[10] Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
[11] Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, Neuherberg, Germany
[12] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
[13] Institut National de la Sante et de la Recherche Médicale (INSERM) Unite Mixte de Recherche (UMR) 1087, Nantes, France
[14] Centre National de la Recherche Scientifique (CNRS) UMR 6291, Nantes, France
[15] Department of Biology, Medicine and Health, Nantes University, Nantes, France
[16] Estonian Genome Center, University of Tartu, Tartu, Estonia
[17] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
[18] Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
[19] Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
[20] Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
[21] Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
[22] Institute of Genetic Epidemiology, Helmholtz Zentrum Muenchen, Neuherberg, Germany
[23] Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany
[24] Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen,, Essen, Germany
[25] CNRS UMR 8199, Institute of Biology and Lille 2 University, Pasteur Institute, Lille, France - Source
Nature genetics. 2012, Vol 44, Num 9, pp 981-990, 10 p ; ref : 49 ref
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Association Diabète de type 2 Génétique Physiopathologie Endocrinopathie Maladie métabolique
- Keyword (en)
- Association Type 2 diabetes Genetics Pathophysiology Endocrinopathy Metabolic diseases
- Keyword (es)
- Asociación Diabetes de tipo 2 Genética Fisiopatología Endocrinopatía Metabolismo patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance / 002B21E01A Etiopathogenesis. Screening. Investigations. Target tissue resistance
- Discipline
- Endocrinopathies Eukaryotes genetics. Biological and molecular evolution
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26341400
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng.2383 
https://dx.doi.org/10.1038/ng.2383
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arXiv access
