Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Author

PEIFER, Martin^{1 2} ; FERNANDEZ-CUESTA, Lynnette^{1 2} ; MENON, Roopika⁸ ; KOKER, Mirjam^{1 2} ; DAHMEN, Ilona^{1 2} ; MÜLLER, Christian^{1 2} ; DI CERBO, Vincenzo⁹ ; SCHILDHAUS, Hans-Ulrich¹⁰ ; ALTMÜLLER, Janine¹¹ ; BAESSMANN, Ingelore¹¹ ; BECKER, Christian¹¹ ; DE WILDE, Bram¹² ; SOS, Martin L^{1 2 3 4} ; VANDESOMPELE, Jo¹² ; BÖHM, Diana⁸ ; ANSEN, Sascha^{3 4} ; GABLER, Franziska² ; WILKENING, Ines² ; HEYNCK, Stefanie² ; HEUCKMANN, Johannes M^{1 2} ; XIN LU^{1 2} ; CARTER, Scott L¹³ ; CIBULSKIS, Kristian¹³ ; GEORGE, Julie^{1 2} ; BANERJI, Shantanu¹³ ; GETZ, Gad¹³ ; PARK, Kwon-Sik^{14 15} ; RAUH, Daniel¹⁶ ; GRÜTTER, Christian¹⁶ ; FISCHER, Matthias^{17 18} ; PASQUALUCCI, Laura^{19 20} ; WRIGHT, Gavin²¹ ; WAINER, Zoe²¹ ; RUSSELL, Prudence²² ; SEIDEL, Danila^{1 2 5} ; PETERSEN, Iver²³ ; YUAN CHEN²³ ; STOELBEN, Erich²⁴ ; LUDWIG, Corinna²⁴ ; SCHNABEL, Philipp²⁵ ; HOFFMANN, Hans; MULEY, Thomas; BROCKMANN, Michael; ENGEL-RIEDEL, Walburga²⁴ ; MUSCARELLA, Lucia A; KASPER, Lawryn H⁶ ; FAZIO, Vito M; GROEN, Harry; TIMENS, Wim; SIETSMA, Hannie; THUNNISSEN, Erik; SMIT, Egbert; HEIDEMAN, Daniëlle A. M; SNIJDERS, Peter J. F; CAPPUZZO, Federico; LIGORIO, Claudia; PLENKER, Dennis^{1 2} ; LEENDERS, Frauke^{1 2 5} ; RUPING SUN⁷ ; ZANDER, Thomas^{1 2 3 4}
[1] Department of Translational Genomics, University of Cologne, Cologne, Germany
[2] Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany
[3] Department I of Internal Medicine, University of Cologne, Cologne, Germany
[4] Center of Integrated Oncology Köln―Bonn, University of Cologne, Cologne, Germany
[5] Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Kölm-Bonn, University of Cologne, Cologne, Germany
[6] Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee, United States
[7] Max Planck Institute for Molecular Genetics, Berlin, Germany
[8] Institute of Prostate Cancer Research at the Institute of Pathology, University Hospital of Bonn, Bonn, Germany
[9] Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
[10] Department of Pathology, University of Cologne, Cologne, Germany
[11] Cologne Center for Genomics, University of Cologne, Cologne, Germany
[12] Center for Medical Genetics, Ghent University, Ghent, Belgium
[13] The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States
[14] Department of Pediatrics, Stanford University, Stanford, California, United States
[15] Department of Genetics, Stanford University, Stanford, California, United States
[16] Department of Chemical Biology, Technical University Dortmund, Dortmund, Germany
[17] Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Cologne, Germany
[18] Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
[19] Institute for Cancer Genetics, Columbia University, New York, New York, United States
[20] Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, United States
[21] Department of Surgery, St. Vincent's Hospital, The University of Melbourne, Melbourne, Victoria, Australia
[22] Department of Pathology, St. Vincent's Hospital, Melbourne, Victoria, Australia
[23] Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany
[24] Department of Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln, Cologne, Germany
[25] Institute of Pathology, Heidelberg, Germany

Source

Nature genetics. 2012, Vol 44, Num 10, pp 1104-1110, 7 p ; ref : 81 ref

CODEN

NGENEC

ISSN

1061-4036

Scientific domain

Genetics

Publisher

Nature Publishing Group, New York, NY

Publication country

United States

Document type

Article

Language

English

Keyword (fr)

Carcinome petite cellule Génome Identification Mutation somatique Poumon Tumeur maligne Appareil respiratoire Cancer

Keyword (en)

Small cell carcinoma Genome Identification Somatic mutation Lung Malignant tumor Respiratory system Cancer

Keyword (es)

Carcinoma célula de avena Genoma Identificación Mutación somática Pulmón Tumor maligno Aparato respiratorio Cáncer

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution

Discipline

Eukaryotes genetics. Biological and molecular evolution

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

26418896

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS