EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2―activating mutations
- Author
- MCCABE, Michael T1 ; OTT, Heidi M1 ; LAFRANCE, Louis V1 ; MELLINGER, Mark1 ; DUQUENNE, Celine1 ; XINRONG TIAN1 ; KRUGER, Ryan G1 ; MCHUGH, Charles F1 ; BRANDT, Martin2 ; MILLER, William H1 ; DHANAK, Dashyant1 ; VERMA, Sharad K1 ; GANJI, Gopinath1 ; TUMMINO, Peter J1 ; CREASY, Caretha L1 ; KORENCHUK, Susan1 ; THOMPSON, Christine1 ; VAN ALLER, Glenn S1 ; VAN LIU1 ; GRAVES, Alan P2 ; DELLA PIETRA, Anthony1 ; DIAZ, Elsie2
[1] Cancer Epigenetics Discovery Performance Unit, Cancer Research, Oncology R&D, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, United States
[2] Platform Technologyand Sciences, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, United States - Source
Nature (London). 2012, Vol 492, Num 7427, pp 108-112, 5 p ; ref : 28 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Animal Anticancéreux Chimiothérapie Homme In vitro In vivo Inhibiteur enzyme Inhibiteur Lignée cellulaire établie Lymphome diffus à grandes cellules B Methyltransferases Répresseur transcription Souris GSK126 Gène Ezh2 Lignée KARPAS-422 Lignée WSU-DLCL2 Cancer Enzyme Hémopathie maligne Lymphome non hodgkinien Mammalia Rodentia Syndrome lymphoprolifératif Traitement Transferases Vertebrata
- Keyword (en)
- Biological activity Animal Antineoplastic agent Chemotherapy Human In vitro In vivo Enzyme inhibitor Inhibitor Established cell line Diffuse large B cell lymphoma Methyltransferases Transcription repressor Mouse Ezh2 gene Cancer Enzyme Malignant hemopathy Non Hodgkin lymphoma Mammalia Rodentia Lymphoproliferative syndrome Treatment Transferases Vertebrata
- Keyword (es)
- Actividad biológica Animal Anticanceroso Quimioterapia Hombre In vitro In vivo Inhibidor enzima Inhibidor Línea celular establecida Linfoma difuso de grandes células B Methyltransferases Represor transcripción Ratón Cáncer Enzima Hemopatía maligna Linfoma no Hodgkin Mammalia Rodentia Linfoproliferativo síndrome Tratamiento Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
- Discipline
- Blood diseases Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26650133
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature11606 
https://dx.doi.org/10.1038/nature11606
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