A Practical Synthesis of (S)-tert-Butyl 3-Methyl-1,4-diazepane-1-carboxylate, the Key Intermediate of Rho―Kinase Inhibitor K-115
- Author
- GOMI, Noriaki1 ; KOUKETSU, Akiyasu1 ; OHGIYA, Tadaaki1 ; SHIBUYA, Kimiyuki1
[1] Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co., Ltd., 2-17-43, Noguchicho, Higashimurayama, Tokyo 189-0022, Japan - Source
Synthesis (Stuttgart). 2012, Num 20, pp 3171-3178, 8 p ; ref : 16 ref
- CODEN
- SYNTBF
- ISSN
- 0039-7881
- Scientific domain
- Organic chemistry
- Publisher
- Thieme, Stuttgart
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- 1,4-diazepane Fukuyama―Mitsunobu cyclization Rho―kinase inhibitor asymmetric molecule cation-exchange resin
- Keyword (fr)
- Alcool Carboxylate Cation Composé chiral Cyclisation Diamine Inhibiteur enzyme Molécule asymétrique Non-specific serine/threonine protein kinase Réaction Mitsunobu Réaction intramoléculaire Synthèse chimique 1,4-Diazépane dérivé Enzyme Transferases
- Keyword (en)
- Alcohol Carboxylate Cations Chiral compound Cyclization Diamine Enzyme inhibitor Asymmetric molecule Non-specific serine/threonine protein kinase Mitsunobu reaction Intramolecular reaction Chemical synthesis Enzyme Transferases
- Keyword (es)
- Alcohol Carboxilato Cation Compuesto quiral Ciclización Diamina Inhibidor enzima Molécula asimétrica Non-specific serine/threonine protein kinase Reacción Mitsunobu Reacción intramolecular Síntesis química Enzima Transferases
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06C Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26673361
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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