Automated design of ligands to polypharmacological profiles
- Author
- BESNARD, Jeremy1 ; FILIPPO RUDA, Gian1 ; SIMEONS, Frederick R. C1 ; STOJANOVSKI, Laste1 ; PRAT, Annik5 ; SEIDAH, Nabil G5 ; CONSTAM, Daniel B6 ; RICHARD BICKERTON, G1 ; READ, Kevin D1 ; WETSEL, William C3 7 ; GILBERT, Ian H1 ; ROTH, Bryan L2 4 ; SETOLA, Vincent2 ; HOPKINS, Andrew L1 ; ABECASSIS, Keren1 ; RODRIGUIZ, Ramona M3 ; HUANG, Xi-Ping2 ; NORVAL, Suzanne1 ; SASSANO, Maria F4 ; SHIN, Antony I3 ; WEBSTER, Lauren A1
[1] Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 SEH, United Kingdom
[2] NIMH Psychoactive Drug Screening Program, Department of Pharmacology, The University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina 27759, United States
[3] Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical School, Durham, North Carolina 27710, United States
[4] Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, The University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina 27759, United States
[5] Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal (IRCM), affiliated with the University of Montreal, Montreal, Quebec, H2W 1R7, Canada
[6] Ecole Polytechnlque Fédérale de Lausanne (EPFL) SV ISREC, Station 19, 1015 Lausanne, Switzerland
[7] Departments of Psychiatry and Behavioral Sciences, Cell Biology, and Neurobiology, Duke University Medical School, Durham, North Carolina 27710, United States - Source
Nature (London). 2012, Vol 492, Num 7428, pp 215-220, 6 p ; ref : 50 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Anticholinestérasique Automatisation Conception Encéphale Ligand Médicament Recherche et développement Récepteur couplé protéine G Technologie pharmaceutique Système nerveux central
- Keyword (en)
- Animal Anticholinesterase agent Automation Design Encephalon Ligand Drug Research and development G protein coupled receptor Pharmaceutical technology Central nervous system
- Keyword (es)
- Animal Anticolinesterasa agente Automatización Diseño Encéfalo Ligando Medicamento Investigación desarrollo Receptor acoplado proteína G Tecnología farmacéutica Sistema nervioso central
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A03 Pharmaceutical technology. Pharmaceutical industry
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26685791
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature11691 
https://dx.doi.org/10.1038/nature11691
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