The IgA1 immune complex―mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy

Author

TAMOUZA, Houda^{1 2} ; CHEMOUNY, Jonathan M^{1 2 3} ; TISSANDIE, Emilie^{1 2} ; TIWARI, Meetu K^{1 2} ; CAMARA, Niels O. S¹¹ ; VRTOVSNIK, François^{1 2 3} ; BENHAMOU, Marc^{1 2} ; NOVAK, Jan⁴ ; MONTEIRO, Renato C^{1 12 2} ; MOURA, Ivan C^{1 2} ; RASKOVA KAFKOVA, Leona⁴ ; BERTHELOT, Laureline^{1 2} ; FLAMANT, Martin^{1 2 5} ; DEMON, Marie^{1 2} ; MESNARD, Laurent^{6 7 8} ; PAUBELLE, Etienne^{1 2} ; WALKER, Francine⁹ ; JULIAN, Bruce A^{10 4}
[1] INSERM U699, Paris, France
[2] Université Paris 7-Denis Diderot, Paris, France
[3] Service de Néphrologie, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France
[4] Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States
[5] Service de Physiologie―Explorations Fonctionnelles, Hôpital Bichat, Assistance Publique―Hôpitaux de Paris, Paris, France
[6] Urgences Néphrologiques et Transplantation Rénale, Hôpital Tenon, APHP, Paris, France
[7] INSERM U702, Paris, France
[8] Université Paris 6- Pierre et Marie Curie, Paris, France
[9] Service d'Anatomo-Pathologie, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France
[10] Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States
[11] Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, Brazil
[12] Service d'Immunologie, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France

Source

Kidney international. 2012, Vol 82, Num 12, pp 1284-1296, 13 p ; ref : 66 ref

CODEN

KDYIA5

ISSN

0085-2538

Scientific domain

Urology, nephrology

Publisher

Nature Publishing Group, Basingstoke

Publication country

United Kingdom

Document type

Article

Language

English

Author keyword

IgA deposition IgA nephropathy IgA

Keyword (fr)

Cellule mésangiale Dépôt Extracellular signal-regulated protein kinase IgA1 IgA Immuncomplexe Immunostimulation Kinase Lésion Mitogen-activated protein kinase Néphrologie Néphropathie glomérulaire à IgA Urologie Appareil urinaire Enzyme Glomérule rénal Immunopathologie Pathologie de l'appareil urinaire Pathologie du rein Rein Transferases

Keyword (en)

Mesangial cell Deposition Extracellular signal-regulated protein kinase IgA1 IgA Immune complex Immunostimulation Kinase Lesion Mitogen-activated protein kinase Nephrology IgA glomerular nephropathy Urology Urinary system Enzyme Renal glomerulus Immunopathology Urinary system disease Kidney disease Kidney Transferases

Keyword (es)

Célula mesangial Depósito Extracellular signal-regulated protein kinase IgA1 IgA Inmunocomplejo Inmunoestimulación Kinase Lesión Mitogen-activated protein kinase Nefrología Nefropatía glomerular IgA Urología Aparato urinario Enzima Glomérulo renal Inmunopatología Aparato urinario patología Riñón patología Riñón Transferases

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B14 Nephrology. Urinary tract diseases / 002B14A Nephropathies. Renovascular diseases. Renal failure / 002B14A01 Glomerulonephritis

Discipline

Nephrology. Urinary tract diseases

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

26691989

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS