The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)2, d(CGATCG)2 and d(CGCGCG)2 shows a strong but reversible binding to G:C base pairs
- Author
- MAZZINI, Stefania1 ; SCAGLIONI, Leonardo1 ; MONDELLI, Rosanna1 ; CARUSO, Michele2 ; SIRTORI, Federico Riccardi3
[1] DeFENS-Department of Food, Environmental and Nutritional Sciences, via Celoria 2, 20133 Milano, Italy
[2] Nerviano Medical Sciences, Oncology-Medicinal Chemistry Department, viale Pasteur 10, 20014 Nerviano (Milano), Italy
[3] Nerviano Medical Sciences, Oncology-Chemical Core Technologies Department, viale Pasteur 10, 20014 Nerviano (Milano), Italy - Source
Bioorganic & medicinal chemistry. 2012, Vol 20, Num 24, pp 6979-6988, 10 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Drug-DNA interactions NMR spectroscopy Nemorubicin Topoisomerase inhibitors
- Keyword (fr)
- Anticancéreux Appariement base DNA topoisomerase Fixation biologique Inhibiteur de la topoisomérase I Inhibiteur enzyme Interaction médicamenteuse Métabolite Némorubicine Spectrométrie RMN Fixation DNA Anthracyclines Enzyme Isomerases
- Keyword (en)
- Antineoplastic agent Base pairing DNA topoisomerase Biological fixation Topoisomerase I inhibitor Enzyme inhibitor Drug interaction Metabolite Nemorubicin NMR spectrometry Anthracyclins Enzyme Isomerases
- Keyword (es)
- Anticanceroso Apareamiento base DNA topoisomerase Fijación biológica Inhibidor topoisomerase I Inhibidor enzima Interacción medicamentosa Metabolito Nemorubicina Espectrometría RMN Antraciclinas Enzima Isomerases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26727231
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2012.10.033 
https://dx.doi.org/10.1016/j.bmc.2012.10.033
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