The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography―tandem mass spectrometric method of a specific probe buspirone
- Author
- LIJUN ZHU1 ; XIAOSHAN YANG1 ; JUAN ZHOU1 ; LAN TANG1 ; BIJUN XIA1 ; MING HU1 3 ; FUYUAN ZHOU2 ; ZHONGQIU LIU1
[1] Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
[2] Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
[3] Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, United States - Source
Food and chemical toxicology. 2013, Vol 51, pp 396-403, 8 p ; ref : 3/4 p
- CODEN
- FCTOD7
- ISSN
- 0278-6915
- Scientific domain
- Food science technology; Toxicology
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Aconitine Buspirone CYP3A Drug-drug interaction UPLC-MS/MS
- Keyword (fr)
- Activité biologique Animal Buspirone Cytochrome P450 Exposition Expression génique Interaction médicamenteuse Isozyme Psychotrope Rat Sonde Spectrométrie masse Toxicité Tranquillisant Aconitine Chromatographie UPLC Cytochrome CYP3A Cytochrome P450 3A Agoniste Composé biochimique Enzyme Mammalia Méthode physique Rodentia Récepteur sérotoninergique 5-HT1A Vertebrata
- Keyword (en)
- Biological activity Animal Buspirone Cytochrome P450 Exposure Gene expression Drug interaction Isozyme Psychotropic Rat Probe Mass spectrometry Toxicity Tranquillizer Ultra performance liquid chromatography Agonist Biochemical compound Enzyme Mammalia Physical method Rodentia 5-HT1A Serotonine receptor Vertebrata
- Keyword (es)
- Actividad biológica Animal Buspirona Citocromo P450 Exposición Expresión genética Interacción medicamentosa Isozima Psicotropo Rata Sonda Espectrometría masa Toxicidad Tranquilizante Agonista Compuesto bioquímico Enzima Mammalia Método físico Rodentia Receptor serotoninérgico 5-HT1A Vertebrata
- Classification
- Discipline
- Toxicology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26780632
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.fct.2012.10.008 
https://dx.doi.org/10.1016/j.fct.2012.10.008
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