Increased CDA Expression/Activity in Males Contributes to Decreased Cytidine Analog Half-Life and Likely Contributes to Worse Outcomes with 5-Azacytidine or Decitabine Therapy
- Author
- MAHFOUZ, Reda Z1 ; JANKOWSKA, Ania1 ; ENGELKE, Kory J7 ; SEKERES, Mikkael A2 ; TIU, Ramon1 2 ; MACIEJEWSKI, Jaroslaw1 2 ; RADIVOYEVITCH, Tomas3 ; SAUNTHARARAJAH, Yogen1 2 ; EBRAHEM, Quteba1 ; XIAORONG GU4 ; VISCONTE, Valeria1 ; TABARROKI, Ali1 ; TERSE, Pramod4 ; COVEY, Joseph5 ; CHAN, Kenneth6 ; YONGHUA LING6
[1] Department of Translational Hematology & Oncology Research, Cleveland Clinic, United States
[2] Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, United States
[3] Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States
[4] NCTT, Division of Pre-Clinical Innovations, National Center for Advancing Translational Sciences, United States
[5] Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and diagnosis, NCI, NIH, Bethesda, Maryland, United States
[6] College of Pharmacy, The Ohio State University, Columbus, Ohio, United States
[7] AVANZA Laboratories, Gaithersburg, Maryland, United States - Source
Clinical cancer research (Print). 2013, Vol 19, Num 4, pp 938-948, 11 p ; ref : 49 ref
- CODEN
- CCREF4
- ISSN
- 1078-0432
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Anticancéreux Azacitidine Cytidine Demi vie Décitabine Expression génique Mâle Pronostic Traitement Analogue de nucléoside Antimétabolite Azanucléoside Dérivé de la triazine Pyrimidine nucléoside
- Keyword (en)
- Biological activity Antineoplastic agent Azacitidine Cytidine Half life Decitabine Gene expression Male Prognosis Treatment Nucleoside analog Antimetabolic Azanucleoside Triazine derivatives Pyrimidine nucleoside
- Keyword (es)
- Actividad biológica Anticanceroso Azacitidina Citidina Media vida Decitabina Expresión genética Macho Pronóstico Tratamiento Análogo nucleósido Antimetabólito Azanucleósido Triazina derivado Pirimidina nucleósido
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 26906716
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1158/1078-0432.CCR-12-1722 
https://dx.doi.org/10.1158/1078-0432.CCR-12-1722
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